449753-95-1Relevant articles and documents
A simple method for the preparation of (5Z,8Z,11Z,14Z)-16-Hydroxyeicosa-5,8,11,14-tetraenoic acid enantiomers and the corresponding 14,15-Dehydro analogues: Role of the 16-Hydroxy group for the lipoxygenase reaction
Ivanov, Igor V.,Romanov, Stepan G.,Groza, Nataliya V.,Nigam, Santosh,Kuhn, Hartmut,Myagkova, Galina I.
, p. 2335 - 2343 (2002)
(5Z,8Z,11Z,13E)-15-Hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) is not well oxygenated by arachidonate 15-lipoxygenases because of two structural reasons: (i) it contains a hydrophilic OH-group in close proximity to its methyl end and (ii) it lacks t