4498-71-9

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indazole, 3-ethylis used as an intermediate in the synthesis of pharmaceuticals for its biological activities, including anti-inflammatory, antibacterial, and antifungal properties, which contribute to the development of new drugs.
Used in Agrochemical Industry:
1H-Indazole, 3-ethylis used as an intermediate in the synthesis of agrochemicals, leveraging its biological activities to develop compounds that can protect crops from various pathogens and pests.
Used in Dye and Pigment Production:
1H-Indazole, 3-ethylis used in the production of dyes and pigments, taking advantage of its chemical properties to create a range of colorants for various applications.
Used in Rubber Chemical Industry:
1H-Indazole, 3-ethylis used in the production of rubber chemicals, where its properties can enhance the performance of rubber products.
Safety Considerations:
1H-Indazole, 3-ethylis considered a hazardous substance and should be handled with care due to its potential health and environmental risks. Proper safety measures and disposal methods should be followed to minimize any adverse effects.

Upstream product

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Relevant academic research and scientific papers

Switchable Synthesis of 3-Substituted 1H-Indazoles and 3,3-Disubstituted 3H-Indazole-3-phosphonates Tuned by Phosphoryl Groups

3-Alkyl/aryl-1H-indazoles and 3-alkyl/aryl-3H-indazole-3-phosphonates were synthesized efficiently through a 1,3-dipolar cycloaddition reaction between α-substituted α-diazomethylphosphonates and arynes under simple reaction conditions. The product distribution was controlled by the phosphoryl group, which acted both as a tuning group and a traceless group in the reaction.

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-activity relationships led to the discovery of ML212.

INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF

The present invention relates to a novel indazole- or pyrrolopyridine-derivative, represented by the formula (1) below, that has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same. Formula (1) [wherein each substituent is as defined in claim 1]

METHOD OF SYNTHESIZING 1H-INDAZOLE COMPOUNDS

A method is provided for synthesizing 1H-indazole compounds in which aromatic carbonyl compounds are reacted with a nitrogen source to form oximes which are then converted to 1H-indazoles.

A practical, metal-free synthesis of 1H-Lndazoles

The synthesis of 1H-indazoles is achieved from o-aminobenzoximes by the selective activation of the oxime in the presence of the amino group. The reaction occurs with a variety of substituted o-aminobenzoximes using a slight excess of methanesulfonyl chloride and triethylamine at 0-23 °C and is amenable to scale-up. The synthesis of 1 H-indazoles under these conditions is extremely mild compared with previous synthetic approaches and affords the desired compounds in good to excellent yields.

A Novel Approach to 1H-Indazoles via Arylazosulfides

Treatment of variously substituted (o-alkylaryl)azosulfides 1a-n with potassium tert-butoxide in DMSO at room temperature smoothly furnishes 1H-indazoles 2a-n.