4500-28-1

Basic information

• Product Name: 3-cyclopentyl-N-phenylpropanamide
• CAS NO: 4500-28-1
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.3068
• Mol File: 4500-28-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 397.4°C at 760 mmHg
• Flash Point: 239.7°C
• Density: 1.066g/cm³
• Vapor Pressure: 1.59E-06mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 3-cyclopentyl-N-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclopentyl-N-phenylpropanamide(4500-28-1)
• EPA Substance Registry System: 3-cyclopentyl-N-phenylpropanamide(4500-28-1)

Safety Data

• Hazardous Substances Data: 4500-28-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 104-97-2 cyclopentanepropanoyl chloride 
• 946513-95-7 1,3-dioxoisoindolin-2-yl cyclopentanecarboxylate 
• 2210-24-4 N-acryloylaniline 
• 140-77-2 3-cyclopentylpropionic acid 
• 153035-24-6 N-Phenyl-2-(trimethylsilyl)propenamide 
• 103-71-9 phenyl isocyanate 
• 153035-37-1 3-Cyclopentyl-N-phenyl-2-trimethylsilanyl-propionamide 

Downstream Products

• 549537-01-1 N-(4-bromophenyl)-3-cyclopentylpropanamide 

Relevant articles and documents

Tungsten-Catalyzed Transamidation of Tertiary Alkyl Amides

Transamidation has recently emerged as a straightforward and convenient means to diversify amides. However, the kinetically and thermodynamically demanding transamidation of notoriously robust, fully alkyl-substituted tertiary amides still remains a longstanding challenge. Here, we describe a method for the activation of tertiary alkyl amides to streamline transamidation using simple tungsten(VI) chloride as a catalyst and chlorotrimethylsilane as an additive. The highly electrophilic and oxophilic tungsten catalyst enables the selective scission of a C-N bond of tertiary alkyl amides to effect transamidation of a myriad of structurally and electronically diverse tertiary alkyl amides and amines. Mechanistic study implies that the synergistic effect of the catalyst and the additive could pronouncedly induce the nucleophilic acyl substitution of tertiary alkyl amide with amine to realize transamidation.

Thiophenol-Catalyzed Visible-Light Photoredox Decarboxylative Couplings of N-(Acetoxy)phthalimides

We have developed visible-light photoredox decarboxylative couplings of N-(acetoxy)phthalimides without an added photocatalyst in which simple and commercially available thiophenols are used as the effective organocatalysts, and 4-(trifluoromethyl)thiophenol shows optimal catalytic activity. Three representative decarboxylative examples were chosen including one amination and two C-C bond couplings to confirm efficacy of the visible-light photoredox reactions, and the results exhibited that they performed very well at room temperature. The interesting discovery should provide a novel and environmentally friendly strategy for visible-light photoredox transformation of organic molecules.