Welcome to LookChem.com Sign In|Join Free

CAS

  • or

140-77-2

Post Buying Request

140-77-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

140-77-2 Usage

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

Cypionic Acid, can be used as an organic building blocks in the synthesis of variety of pharmaceutical compound. It is used for the synthesis of Testosterone Cypionate (T155100).

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the methyl hydrogens is substituted by a cyclopentyl group.

Check Digit Verification of cas no

The CAS Registry Mumber 140-77-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 140-77:
(5*1)+(4*4)+(3*0)+(2*7)+(1*7)=42
42 % 10 = 2
So 140-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H14O2/c9-8(10)6-5-7-3-1-2-4-7/h7H,1-6H2,(H,9,10)/p-1

140-77-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A18192)  3-Cyclopentylpropionic acid, 98%   

  • 140-77-2

  • 25g

  • 733.0CNY

  • Detail
  • Alfa Aesar

  • (A18192)  3-Cyclopentylpropionic acid, 98%   

  • 140-77-2

  • 100g

  • 2053.0CNY

  • Detail

140-77-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-cyclopentylpropionic acid

1.2 Other means of identification

Product number -
Other names Cyclopentanepropionic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:140-77-2 SDS

140-77-2Synthetic route

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

cyclopentanealdehyde
872-53-7

cyclopentanealdehyde

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With formic acid; triethylamine at 100℃; Knoevenagel condensation;89%
cyclopentanone
120-92-3

cyclopentanone

isobutyric Acid
79-31-2

isobutyric Acid

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide79.2%
With potassium hydroxide; sodium hydroxide17.8%
3-cyclopentyl-1-propanol
767-05-5

3-cyclopentyl-1-propanol

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide; zinc(II) oxide In 1,3,5-trimethyl-benzene at 164℃; for 36h; Inert atmosphere; Schlenk technique;74%
Cyclopentanol
96-41-3

Cyclopentanol

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
72%
3-cyclopentylpropanol methyl ether

3-cyclopentylpropanol methyl ether

A

3-cyclopentylpropanal
6053-89-0

3-cyclopentylpropanal

B

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With HOF* CH3CN; sodium fluoride In chloroform; water; acetonitrile 0 deg C -> room temperature;A 15%
B 70%
succinic acid anhydride
108-30-5

succinic acid anhydride

Cyclopentyl bromide
137-43-9

Cyclopentyl bromide

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h;57%
2-Ethylbutanoic acid
88-09-5

2-Ethylbutanoic acid

cyclopentanone
120-92-3

cyclopentanone

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide; sodium hydroxide13.8%
3-cyclopentylpropionitrile
1123-04-2

3-cyclopentylpropionitrile

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With sodium hydroxide
With sodium hydroxide In ethanol
(+/-)-3c-cyclopent-2-enyl-acrylic acid
90953-67-6

(+/-)-3c-cyclopent-2-enyl-acrylic acid

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With palladium Hydrogenation;
bicyclo[3.2.1]octan-2-one
5019-82-9

bicyclo[3.2.1]octan-2-one

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
In tetrahydrofuran; water Irradiation;
3-(cyclopent-2-enyl)-propionaldehyde
64504-73-0

3-(cyclopent-2-enyl)-propionaldehyde

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
(i) AgNO3, aq. NaOH, dioxane, (ii) H2, Pd-C, AcOEt; Multistep reaction;
3-(2-oxocyclopentyl)propionic acid
3296-45-5

3-(2-oxocyclopentyl)propionic acid

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With hydrogenchloride; tin
3-cyclopentanepropanoic acid p-nitrophenyl ester

3-cyclopentanepropanoic acid p-nitrophenyl ester

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With sodium hydroxide; sodium hydrogencarbonate; sodium chloride In 1,4-dioxane at 35℃; Rate constant; var. conc. of ester;
(+-)-3-<2-oxo-cyclopentyl>-propionic acid

(+-)-3-<2-oxo-cyclopentyl>-propionic acid

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide; hydrazine hydrate; ethylene glycol
With hydrogenchloride; amalgamated zinc
CH3OCCHCOC6H3OCOCH2CH2CHC4H8

CH3OCCHCOC6H3OCOCH2CH2CHC4H8

A

7-hydroxy-4-methyl-chromen-2-one
90-33-5, 79566-13-5

7-hydroxy-4-methyl-chromen-2-one

B

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
With water In phosphate buffer pH=7.2; Enzyme kinetics;
(2-bromo-ethyl)-cyclopentane
18928-94-4

(2-bromo-ethyl)-cyclopentane

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: aqueous NaOH
View Scheme
ethyl cyclopentylacetate
18322-54-8

ethyl cyclopentylacetate

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium alanate; diethyl ether
2: hydrogen bromide
4: aqueous NaOH
View Scheme
2-cyclopentyl-ethanol
766-00-7

2-cyclopentyl-ethanol

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen bromide
3: aqueous NaOH
View Scheme
7-chlorobicyclo<2.2.1>hepta-2,5-diene
1609-39-8

7-chlorobicyclo<2.2.1>hepta-2,5-diene

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) aq. EtOH, (ii) H2, Pd-C
2: NaOH / aq. ethanol
View Scheme
2-(2-Aethoxycarbonyl-aethyl)-2-cyan-cyclopentanon-(1)
91247-75-5

2-(2-Aethoxycarbonyl-aethyl)-2-cyan-cyclopentanon-(1)

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl
2: Sn, aq. HCl
View Scheme
2-oxocyclopentanecarbonitrile
2941-29-9

2-oxocyclopentanecarbonitrile

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KOH, MeOH / benzene
2: aq. HCl
3: Sn, aq. HCl
View Scheme
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

cyclopentanepropanoyl chloride
104-97-2

cyclopentanepropanoyl chloride

Conditions
ConditionsYield
With thionyl chloride In toluene Heating;100%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 23℃;100%
With pyridine; thionyl chloride for 5h; Reflux;83.85%
tert-butyl tetrahydropyrimidin-1(2H)-carboxylic acid

tert-butyl tetrahydropyrimidin-1(2H)-carboxylic acid

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

tert-butyl 3-(3-cyclopentylpropanoyl)tetrahydropyrimidine-1(2H)-carboxylate

tert-butyl 3-(3-cyclopentylpropanoyl)tetrahydropyrimidine-1(2H)-carboxylate

Conditions
ConditionsYield
With COMU; N-ethyl-N,N-diisopropylamine In dichloromethane at 22℃;97%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-Phenylpropan-1-amine
2038-57-5

3-Phenylpropan-1-amine

3-cyclopentyl-N-(3-phenylpropyl)propanamide

3-cyclopentyl-N-(3-phenylpropyl)propanamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 12h; Inert atmosphere;95%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

1,3-dioxoisoindolin-2-yl 3-cyclopentylpropanoate

1,3-dioxoisoindolin-2-yl 3-cyclopentylpropanoate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 18h;94%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique;
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;
(5-(3-bromo-4-hydroxybenzylidene)thiazolidine-2,4-dione)

(5-(3-bromo-4-hydroxybenzylidene)thiazolidine-2,4-dione)

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

((Z)-2-bromo-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 3-cyclopentylpropanoate)

((Z)-2-bromo-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: (5-(3-bromo-4-hydroxybenzylidene)thiazolidine-2,4-dione); 3-cyclopentylpropionic acid With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
93.4%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

(5-(2-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione)

(5-(2-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione)

((Z)-3-chloro-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl-3-cyclopentylpropanoate)

((Z)-3-chloro-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl-3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: 3-cyclopentylpropionic acid; (5-(2-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione) With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
93.3%
(3,5-dichloropyridin-4-yl)hydrazine
153708-69-1

(3,5-dichloropyridin-4-yl)hydrazine

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-cyclopentyl-N'-(3,5-dichloropyridin-4-yl)propanehydrazide
1370287-06-1

3-cyclopentyl-N'-(3,5-dichloropyridin-4-yl)propanehydrazide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;93%
(Z)-5-(4-hydroxyphenylmethylene)-2,4-thiazolidinedione
103788-60-9

(Z)-5-(4-hydroxyphenylmethylene)-2,4-thiazolidinedione

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl-3-cyclopentylpropanoate)

((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl-3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: (Z)-5-(4-hydroxyphenylmethylene)-2,4-thiazolidinedione; 3-cyclopentylpropionic acid With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
92.4%
hex-3-yne
928-49-4

hex-3-yne

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

(Z)-hex-3-en-3-yl 3-cyclopentylpropanoate

(Z)-hex-3-en-3-yl 3-cyclopentylpropanoate

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; silver(I) acetate In water at 60℃; for 12h; Inert atmosphere; Sealed tube; Green chemistry; stereoselective reaction;91%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 3-cyclopentylpropanoate)

((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-ethoxyphenyl 3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: 3-cyclopentylpropionic acid; PIM-2 With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
90.2%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-cyclopentyl-1-propanol
767-05-5

3-cyclopentyl-1-propanol

Conditions
ConditionsYield
With dimethylsulfide borane complex Reduction;90%
With lithium aluminium tetrahydride
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #1: 3-cyclopentylpropionic acid With phenylsilane; C32H25MnN4O3P(1+)*Br(1-) In tetrahydrofuran at 80℃; for 2h;
Stage #2: With water In tetrahydrofuran
95 %Spectr.
(2S)-2-amino-N-[3-({[4-fluoro-2-(trifluoromethyl)phenyl]sulfonyl}amino)propyl]-2-phenylethanamide
878798-91-5

(2S)-2-amino-N-[3-({[4-fluoro-2-(trifluoromethyl)phenyl]sulfonyl}amino)propyl]-2-phenylethanamide

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-cyclopentyl-N-((1S)-2-{[3-({[4-fluoro-2-(trifluoromethyl)phenyl]sulfonyl}amino)propyl]amino}-2-oxo-1-phenylethyl)propanamide

3-cyclopentyl-N-((1S)-2-{[3-({[4-fluoro-2-(trifluoromethyl)phenyl]sulfonyl}amino)propyl]amino}-2-oxo-1-phenylethyl)propanamide

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one In dichloromethane at 20℃;90%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

(5-(3-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione)

(5-(3-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione)

((Z)-2-chloro-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 3-cyclopentylpropanoate)

((Z)-2-chloro-4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: 3-cyclopentylpropionic acid; (5-(3-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione) With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
89.3%
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidine-2,4-dione
911714-34-6

(5Z)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidine-2,4-dione

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenyl-3-cyclopentylpropanoate)

((Z)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenyl-3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: (5Z)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidine-2,4-dione; 3-cyclopentylpropionic acid With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
88.8%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

trifluoroborane diethyl ether
109-63-7

trifluoroborane diethyl ether

3-cyclopentyl-1-propanol
767-05-5

3-cyclopentyl-1-propanol

Conditions
ConditionsYield
With sodium borohydrid; dimethylsulfide In tetrahydrofuran87.5%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

trimethylsilyl 3-(cyclopropyl)propionate
934415-17-5

trimethylsilyl 3-(cyclopropyl)propionate

Conditions
ConditionsYield
Stage #1: 3-cyclopentylpropionic acid With pyridine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: chloro-trimethyl-silane With 1,1,1,3,3,3-hexamethyl-disilazane In tetrahydrofuran at 0 - 20℃; for 12h;
84%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

bis(3-cyclopentylpropanoyl) peroxide
955017-60-4

bis(3-cyclopentylpropanoyl) peroxide

Conditions
ConditionsYield
With dmap; dihydrogen peroxide; dicyclohexyl-carbodiimide In dichloromethane at -10℃; for 3h;84%
With dmap; dihydrogen peroxide; dicyclohexyl-carbodiimide In dichloromethane at -10℃; for 3h;84%
Stage #1: 3-cyclopentylpropionic acid With dmap; dihydrogen peroxide In dichloromethane at -15℃; for 0.166667h; Inert atmosphere;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at -15 - -10℃; for 1.5h; Inert atmosphere;
pyrrolidine
123-75-1

pyrrolidine

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-cyclopentyl-1-(pyrrolidin-1-yl)propan-1-one
544683-75-2

3-cyclopentyl-1-(pyrrolidin-1-yl)propan-1-one

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;83%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

formaldehyde O-benzyloxime
72399-18-9

formaldehyde O-benzyloxime

3-((benzyloxy)amino)-2-(cyclopentylmethyl)propanoic acid

3-((benzyloxy)amino)-2-(cyclopentylmethyl)propanoic acid

Conditions
ConditionsYield
Stage #1: 3-cyclopentylpropionic acid With chloro-trimethyl-silane; triethylamine; sodium iodide In acetonitrile at 15 - 25℃; Inert atmosphere; Large scale;
Stage #2: formaldehyde O-benzyloxime In acetonitrile at 30℃; for 4h; Inert atmosphere; Large scale;
83%
(1RS,2SR)-2-amino-1-(4-fluorophenyl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

(1RS,2SR)-2-amino-1-(4-fluorophenyl)-3-[4-(trifluoromethyl)phenyl]propan-1-ol

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-cyclopentyl-N-[(1RS,2SR)-2-(4-fluorophenyl)-2-hydroxy-1-[4-(trifluoromethyl)benzyl]ethyl]propionamide

3-cyclopentyl-N-[(1RS,2SR)-2-(4-fluorophenyl)-2-hydroxy-1-[4-(trifluoromethyl)benzyl]ethyl]propionamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃;82%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-fluoro-N4-(4-(trifluoromethyl)benzyl)benzene-1,2,4-triamine

3-fluoro-N4-(4-(trifluoromethyl)benzyl)benzene-1,2,4-triamine

C22H25F4N3O

C22H25F4N3O

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;81.4%
1-iodooct-1-yne
81438-46-2

1-iodooct-1-yne

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

(Z)-1-iodooct-1-en-2-yl 3-cyclopentylpropanoate

(Z)-1-iodooct-1-en-2-yl 3-cyclopentylpropanoate

Conditions
ConditionsYield
With silver(I) hexafluorophosphate; (triphenylphosphine)gold(I) chloride In toluene at 20℃; for 18h; Inert atmosphere; Sealed tube; Darkness; stereoselective reaction;79%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

(5-(2-chloro-3-hydroxybenzylidene)thiazolidine-2,4-dione)

(5-(2-chloro-3-hydroxybenzylidene)thiazolidine-2,4-dione)

((Z)-2-chloro-3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl-3-cyclopentylpropanoate)

((Z)-2-chloro-3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl-3-cyclopentylpropanoate)

Conditions
ConditionsYield
Stage #1: 3-cyclopentylpropionic acid; (5-(2-chloro-3-hydroxybenzylidene)thiazolidine-2,4-dione) With dmap In dichloromethane for 0.0833333h; Cooling with ice;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃;
76.6%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

H-Pro-OBzl
41324-66-7

H-Pro-OBzl

(S)-benzyl 1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxylate
1215172-50-1

(S)-benzyl 1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane76%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

isobutene
115-11-7

isobutene

tert-butyl 3-cyclopentylpropanoate
173674-09-4

tert-butyl 3-cyclopentylpropanoate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane at -78 - 20℃; for 72h; Inert atmosphere;74%
(4-(piperidin-1-yl)phenyl)methanamine
214759-73-6

(4-(piperidin-1-yl)phenyl)methanamine

3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

3-cyclopentyl-N-(4-(piperidin-1-yl)benzyl)propanamide

3-cyclopentyl-N-(4-(piperidin-1-yl)benzyl)propanamide

Conditions
ConditionsYield
With COMU; N-ethyl-N,N-diisopropylamine In dichloromethane at 22℃;74%
3-cyclopentylpropionic acid
140-77-2

3-cyclopentylpropionic acid

(S)-2-(p-tolylsulfinyl)aniline

(S)-2-(p-tolylsulfinyl)aniline

3-cyclopentyl-(S)-N-(2-(p-tolylsulfinyl)phenyl)propionamide

3-cyclopentyl-(S)-N-(2-(p-tolylsulfinyl)phenyl)propionamide

Conditions
ConditionsYield
With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h;73%

140-77-2Relevant articles and documents

Pancrazio

, p. 145 (1957)

Synthetic method of acid compound

-

Paragraph 0028-0033; 0041, (2020/08/25)

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of an acid compound. An acid anhydride compound and an alkyl bromide or a functionalized alkyl bromide are subjected to a cross-electrophilic coupling reaction to synthesize an acid compound, so that the application of the alkyl bromide in the cross-electrophilic coupling reaction is expanded, and a novel non-traditional method for chemically and selectively constructing a carbon-carbon bond through a decarburization process is provided. The synthesis method is simple, economic, green and environment-friendly, and has wider applicability or is suitable for large-scale production.

Structure activity studies with xenobiotic substrates using carboxylesterases isolated from Arabidopsis thaliana

Cummins, Ian,Landrum, Marie,Steel, Patrick G.,Edwards, Robert

, p. 811 - 818 (2008/03/13)

Carboxylesterases (CXEs) catalyse the hydrolysis of xenobiotics and natural products radically altering their biological activities. Whereas the substrate selectivity of animal CXEs, such as porcine liver esterase (PLE) have been well studied, the respective enzymes in plants have yet to be defined and their activities determined. Using Arabidopsis thaliana (At) as a source, five representative members of the α/β hydrolase AtCXE family of proteins have been cloned, expressed and the purified recombinant proteins assayed for esterase activity with xenobiotic substrates. Two members, AtCXE5 and AtCXE18 were found to be active carboxylesterases, though AtCXE5 proved to be highly unstable as a soluble protein. AtCXE18 and the previously characterised S-formylglutathione hydrolase from Arabidopsis (AtSFGH) were assayed against a series of esters based on methylumbelliferone in which the acyl moiety was varied with respect to size and conformation. The same series was used to assay crude esterase preparation from Arabidopsis plants and the results compared with those obtained with the commonly used PLE. With straight chain esters, AtCXE18 behaved like PLE, but the Arabidopsis hydrolases proved less tolerant of branched chain acyl components than the mammalian enzyme. While none of the enzyme preparations accurately reflected all the activities determined with crude Arabidopsis protein extracts, the plant enzymes proved more useful than PLE in predicting the hydrolysis of the more sterically constrained esters.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 140-77-2