450415-78-8 Usage
Uses
Used in Pharmaceutical Industry:
4-(2-BROMOPHENYL)-1H-IMIDAZOLE is used as a chemical intermediate for the synthesis of various drugs, particularly those with antifungal and antiparasitic properties. Its unique structure allows it to be a key component in the development of medications targeting a range of infections and diseases.
Used in Research and Development:
In the realm of scientific research, 4-(2-BROMOPHENYL)-1H-IMIDAZOLE is utilized for the synthesis of other organic compounds. Its versatility in chemical reactions makes it a valuable asset in the creation of new chemical entities for potential applications in medicine and other fields.
Used in Therapeutic Applications:
4-(2-BROMOPHENYL)-1H-IMIDAZOLE is being studied for its potential use in various therapeutic applications due to its known biological activities. While the specific applications are still under investigation, the compound holds promise for contributing to advancements in healthcare and treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 450415-78-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,0,4,1 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 450415-78:
(8*4)+(7*5)+(6*0)+(5*4)+(4*1)+(3*5)+(2*7)+(1*8)=128
128 % 10 = 8
So 450415-78-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7BrN2/c10-8-4-2-1-3-7(8)9-5-11-6-12-9/h1-6H,(H,11,12)
450415-78-8Relevant academic research and scientific papers
Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors
Young, Mary Beth,Barrow, James C.,Glass, Kristen L.,Lundell, George F.,Newton, Christina L.,Pellicore, Janetta M.,Rittle, Kenneth E.,Selnick, Harold G.,Stauffer, Kenneth J.,Vacca, Joseph P.,Williams, Peter D.,Bohn, Dennis,Clayton, Franklin C.,Cook, Jacquelynn J.,Krueger, Julie A.,Kuo, Lawrence C.,Lewis, S. Dale,Lucas, Bobby J.,McMasters, Daniel R.,Miller-Stein, Cynthia,Pietrak, Beth L.,Wallace, Audrey A.,White, Rebecca B.,Wong, Bradley,Yan, Youwei,Nantermet, Philippe G.
, p. 2995 - 3008 (2007/10/03)
In an effort to discover potent, clinically useful thrombin inhibitors, a rapid analogue synthetic approach was used to explore the P1 region. Various benzylamines were coupled to a pyridine/pyrazinone P2-P 3 template. One compound with an o-thiadiazole benzylic substitution was found to have a thrombin Ki of 0.84 nM. A study of ortho-substituted five-membered-ring heterocycles was undertaken and subsequently demonstrated that the o-triazole and tetrazole rings were optimal. Combination of these potent P1 aryl heterocycles with a variety of P2-P3 groups produced a compound with an extraordinary thrombin inhibitory activity of 1.4 pM. It is hoped that this potency enhancement in P1 will allow for more diversification in the P 2-P3 region to ultimately address additional pharmacological concerns.
