4508-82-1

Upstream product

• 125219-11-6 (2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-carbamic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester 
• 67-64-1 acetone 

Downstream Products

• 1194509-18-6 propynoic acid (2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)amide 
• 125219-11-6 (2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-carbamic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester 
• 147781-29-1 (-)-(4R,5R)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane 
• 35019-66-0 (4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine 
• 4508-83-2 (+/-)-dichloroacetic acid-(2,2-dimethyl-4r-phenyl-[1,3]dioxan-5c-ylamide) 

Relevant academic research and scientific papers

Tandem radical and non-radical reactions mediated with thiols - A new method of cleavage of allylic amines

Thiyl radical promotes the isomerisation of allylic amines into enamines via two consecutive hydrogen atom abstraction steps, and the subsequent polar addition of the corresponding thiol to the enamine results in the cleavage of the C-N bond via a thioaminal intermediate: this reaction provides a mild, metal-free methodology for the deprotection of allylated primary and secondary amines.

PHOTOLABILE p-METHOXYPHENACYLOXYCARBONYL GROUP FOR THE PROTECTION OF AMINES

P-Methoxyphenacyloxycarbonyl (Phenoc) is a new photolabile protective group for amines.Various phenacyl urethanes, i.e.Phenoc protected amines, have been prepared.An application of the group in peptide synthesis is reported.