450840-65-0

Basic information

• Product Name: Pyridine, 4-(3-chlorophenyl)-2-fluoro-5-methyl-
• CAS NO: 450840-65-0
• Molecular Formula: C12H9ClFN
• Molecular Weight: 221.662
• Mol File: 450840-65-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(3-chlorophenyl)-2-fluoro-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(3-chlorophenyl)-2-fluoro-5-methyl-(450840-65-0)
• EPA Substance Registry System: Pyridine, 4-(3-chlorophenyl)-2-fluoro-5-methyl-(450840-65-0)

Safety Data

• Hazardous Substances Data: 450840-65-0(Hazardous Substances Data)

Upstream product

• 14221-01-3 tetrakis(triphenylphosphine) palladium⁽⁰⁾ 
• 63503-60-6 3-chlorophenylboronic acid 
• 153034-78-7 2-Fluoro-3-iodo-5-methylpyridine 
• 2369-19-9 2-fluoro-5-methylpyridine 
• 153034-94-7 2-Fluoro-4-iodo-5-methylpyridine 

Downstream Products

• 450840-70-7 5-(bromomethyl)-4-(3-chlorophenyl)-2-fluoropyridine 
• 450840-75-2 4-(3-chlorophenyl)-5-methyl-2-pyridinecarbonitrile 
• 450840-79-6 5-(bromomethyl)-4-(3-chlorophenyl)-2-pyridinecarbonitrile 
• 450837-37-3 4-(((4-(3-chlorophenyl)-6-oxo-1,6-dihydro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 
• 450837-14-6 4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 
• 777096-67-0 4-(3-chloro-phenyl)-1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-2-carbonitrile 
• 777096-64-7 4-(3-chloro-phenyl)-5-methyl-6-oxo-1,6-dihydro-pyridine-2-carbonitrile 

Relevant articles and documents

Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors

The synthesis and biological evaluation of two novel series of potent and selective FTase inhibitors are described. Two novel series of potent and selective FTase inhibitors have been synthesized using structure-based design. Medicinal chemistry efforts led to the discovery of compound 4e with potent cellular activity and good oral bioavailability in dog. A synthetic route toward novel heterocycles 1,5-dimethyl-6-oxo-4-aryl-1,6-dihydro-pyridine-2- carbonitrile was established. The structure of compound 5c was confirmed by X-ray crystallography.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.