450840-98-9

Upstream product

• 1394014-79-9 C₁₄H₁₂ClNO₃ 
• 1394014-67-5 C₈H₈ClNO₃ 
• 1174525-17-7 C₈H₉NO₄ 
• 610271-66-4 dimethyl 2-[(dimethylamino)methylidene]-3-oxopentane-1,5-dioate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 450840-84-3 diethyl (2E)-3-(3-chlorophenyl)-2-pentenedioate 
• 625-99-0 3-iodochlorobenzene 
• 73192-75-3 (Z)-diethyl pent-2-enedioate 
• 450840-94-5 ethyl 4-(3-chlorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate 

Downstream Products

• 1394015-09-8 C₁₈H₂₂ClN₃O₂ 
• 1394015-08-7 C₂₀H₁₇ClN₂O₂ 
• 1394015-07-6 C₁₆H₁₇ClN₂O₃ 

Relevant academic research and scientific papers

Diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6- dihydropyridine-3-carboxamides.

A simple five-step diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxamides was developed. Treatment of dimethyl 2-((dimethylamino)methylidene)-3-oxopentanedioate with twenty primary amines gave 1-substituted methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3- carboxylates. Transformation into the corresponding 4-tosyloxy and 4-chloro derivatives, followed by Suzuki-Miyaura arylations gave a series of eleven N-substituted methyl 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxylates. Combinatorial screening was employed to establish suitable reaction conditions for Suzuki-Miyaura arylation of N-alkylpyridones. Hydrolysis of the esters followed by parallel solution-phase amidation of the corresponding carboxylic acids with primary and secondary amines furnished a library of seventeen final products.

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors

As a part of our efforts to identify potent inhibitors of farnesyltransferase (FTase), modification of the structure of tipifarnib through structure-based design was undertaken by replacing the 2-quinolones with 4-quinolones and pyridones, and subsequent

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.