13739-48-5

Basic information

• Product Name: 2-Methyl-4-phenyl-1H-imidazole
• Synonyms: 2-METHYL-4-PHENYL-1H-IMIDAZOLE;1H-imidazole, 2-methyl-4-phenyl-;2-methyl-4-phenyl-1H-imidazole(SALTDATA: FREE);4-(2-Methyl Phenyl)IMidazole;2-Methyl-5-phenyliMidazole;2-methyl-4-phenyl-3H-imidazole;2-methyl-5-phenyl-1H-imidazole
• CAS NO: 13739-48-5
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Product Categories: Imidazoles & Benzimidazoles
• Mol File: 13739-48-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 159-160.5 °C
• Boiling Point: 396.2 °C at 760 mmHg
• Flash Point: 220.1 °C
• Appearance: /
• Density: 1.109 g/cm³
• Vapor Pressure: 3.98E-06mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.13±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-4-phenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-phenyl-1H-imidazole(13739-48-5)
• EPA Substance Registry System: 2-Methyl-4-phenyl-1H-imidazole(13739-48-5)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 13739-48-5(Hazardous Substances Data)

Usage

General Description

2-Methyl-4-phenyl-1H-imidazole is a chemical compound with the molecular formula C10H10N2. It is an imidazole derivative, which is a heterocyclic compound containing both a carbon and nitrogen atom in its ring structure. 2-Methyl-4-phenyl-1H-imidazole is commonly used as a building block for the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its anti-fungal and anti-cancer properties. Additionally, 2-Methyl-4-phenyl-1H-imidazole has been investigated as a potential ligand for metal complexes in coordination chemistry. Overall, this chemical compound has diverse applications and potential uses in the fields of medicine, agriculture, and materials science.

InChI:InChI=1/C10H10N2/c1-8-11-7-10(12-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,11,12)

Upstream product

• 20662-90-2 2-methyl-4-phenyloxazole 
• 77287-34-4 formamide 
• 21203-79-2 2-methyl-6-phenylpyrimidine 
• 72875-89-9 3-chloro-2-methyl-5-phenyl-pyrazine 
• 64-19-7 acetic acid 
• 70-11-1 α-bromoacetophenone 
• 16265-11-5 5-bromo-2-methyl-1H-imidazole 
• 98-80-6 phenylboronic acid 
• 73746-45-9 4⁽⁵⁾-iodo-2-methyl-1H-imidazole 
• 88346-51-4 2-azido-3-methyl-6-phenylpyrazine 
• 88346-56-9 1-cyano-2-methyl-5-phenylimidazole 
• 124-42-5 acetamidine hydrochloride 
• 536-74-3 phenylacetylene 
• 1135539-10-4 1-(methylsulfonyl)-4-phenyl-1H-1,2,3-triazole 

Downstream Products

• 131013-50-8 2-methyl-5-phenyl-1⁽³⁾H-imidazole-4-carboxylic acid anilide 
• 117043-83-1 4-cyclohexyl-2-methyl-1⁽³⁾H-imidazole 
• 1195774-63-0 C₁₈H₁₇N₃OS 
• 1323403-62-8 3-{4-[4-(2-Methyl-4-phenyl-imidazol-1-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione 
• 93115-69-6 2-methyl-5-phenyl-1⁽³⁾H-imidazol-4-ylamine 
• 23572-07-8 3-benzoyl-5-methyl-1,2,4-oxadiazole 

Relevant articles and documents

General synthesis of C substituted imidazoles.

-

FERROPORTIN INHIBITORS AND METHODS OF USE

The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.

Metal-free synthesis of imidazole by BF3·Et2O promoted denitrogenative transannulation of N-sulfonyl-1,2,3-triazole

BF3·Et2O promoted metal-free denitrogenative transannulation of N-sulfonyl-1,2,3-triazole was reported. Rather than transition metals, BF3·Et2O was employed for the first time to promote the formation of α-diazoimines from N-sulfonyl-1,2,3-triazoles in nitriles, leading to the synthesis of various imidazoles. The protocol tolerates a broad range of functional groups and could also be applied to the late-stage modification of bioactive molecules, demonstrating the potential of this protocol in organic synthesis. A plausible mechanism was proposed.

One-pot synthesis of 2-alkyl-4(5)-aryl-1H-imidazoles from 1-aryl-2-bromoethanones, ammonium carbonate and aliphatic carboxylic acids

A simple and efficient protocol for the preparation of 2-alkyl-4(5)-aryl- 1H-imidazoles starting from α-bromo aryl methyl ketones and aliphatic carboxylic acids in the presence of ammonium carbonate has been developed.