4511-34-6Relevant academic research and scientific papers
Methods and intermediates for the synthesis of porphyrins
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Page/Page column 12-13; 14-15; 27, (2008/06/13)
A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethaneto produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.
Direct synthesis of magnesium porphine via 1-formyldipyrromethane
Dogutan, Dilek Kiper,Ptaszek, Marcin,Lindsey, Jonathan S.
, p. 5008 - 5011 (2008/02/07)
(Chemical Equation Presented) The reaction of 1-formyldipyrromethane (100 mM) in toluene at 115°C containing DBU (10 mol equiv) and MgBr2 (3 mol equiv) in the presence of air affords the magnesium chelate Mg(II) porphine in 30-40% yield. The advantages of the new method include simplicity, high concentration, chromatography-free purification, gram-scale synthesis, and avoidance of the poorly soluble free base porphine. Mg(II) porphine exhibits good solubility in common organic solvents and is a valuable core scaffold for derivatization.
Synthesis and photochemical reactivity of bilirubin model compounds
Groot, J. A. de,Steen, R. van der,Fokkens, R.,Lugtenburg, J.
, p. 35 - 40 (2007/10/02)
The bilirubin model compounds 1, 2 and 3 were prepared in good yield.The photochemistry of 1, 2 and 3, which all have the 4Z,15Z form, was investigated; they show a Z-E isomerisation to the 4Z,15E and the 4E,15E isomers.Unlike the isomers of 1, those of the compounds 2 and 3, could be isolated in a pure form.
