4511-99-3

Basic information

• Product Name: 3-AMINO-5,6-DIPHENYL-1,2,4-TRIAZINE
• Synonyms: 3-AMINO-5,6-DIPHENYL-1,2,4-TRIAZINE;5,6-DIPHENYL-1,2,4-TRIAZIN-3-AMINE;3-amino-3,6-diphenyl-as-triazin;3-AMINO-5,6-DIPHENYL-1,2,4-TRIAZINE 97%
• CAS NO: 4511-99-3
• Molecular Formula: C₁₅H₁₂N₄
• Molecular Weight: 248.28
• Mol File: 4511-99-3.mol

Chemical Properties

• Melting Point: 177 °C
• Boiling Point: 463.6°Cat760mmHg
• Flash Point: 265.2°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 8.94E-09mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 3-AMINO-5,6-DIPHENYL-1,2,4-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5,6-DIPHENYL-1,2,4-TRIAZINE(4511-99-3)
• EPA Substance Registry System: 3-AMINO-5,6-DIPHENYL-1,2,4-TRIAZINE(4511-99-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4511-99-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Manufacturing:
3-Amino-5,6-diphenyl-1,2,4-triazine is used as an intermediate compound for the synthesis of various chemicals. Its presence in the triazine family suggests potential applications in the production of dyes and pharmaceuticals, similar to other triazine derivatives.
Used in Research and Development:
Due to its limited study and application, 3-Amino-5,6-diphenyl-1,2,4-triazine may be utilized in research settings to explore its properties, potential uses, and possible hazards. This could involve investigating its chemical reactivity, stability, and interactions with other compounds, as well as assessing its toxicity and environmental impact.
Used in Pharmaceutical Development:
As a member of the triazine family, 3-Amino-5,6-diphenyl-1,2,4-triazine could be used as a building block in the development of new pharmaceuticals. Its potential role in drug synthesis may be explored through medicinal chemistry research, where it could contribute to the creation of novel therapeutic agents with specific pharmacological properties.
Used in Environmental and Safety Studies:
Given the potential toxicity of some triazine compounds, 3-Amino-5,6-diphenyl-1,2,4-triazine may be studied in the context of environmental and safety assessments. This could involve evaluating its effects on ecosystems, determining appropriate disposal methods, and establishing safety guidelines for handling and storage.

InChI:InChI=1/C15H12N4/c16-15-17-13(11-7-3-1-4-8-11)14(18-19-15)12-9-5-2-6-10-12/h1-10H,(H2,16,17,19)

Upstream product

• 2582-30-1 aminoguanidine bicarbonate 
• 134-81-6 benzil 
• 83413-00-7 3-(methylsulfonyl)-5-phenyl-1,2,4-triazine 
• 942-60-9 5-phenyl-1,2,4-triazin-3-amine 
• 28735-27-5 3-methylthio-5-phenyl-1,2,4-triazine 
• 1321517-51-4 6-bromo-5-phenyl-1,2,4-triazin-3-amine 
• 98-80-6 phenylboronic acid 
• 272773-77-0 C₂₁H₂₅N₆O₃P 
• 88281-91-8 3-azido-5,6-diphenyl-1,2,4-triazine 
• 10308-82-4 aminoguanidine nitrate 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 

Downstream Products

• 108595-51-3 6-[1]naphthyl-2,3,7-triphenyl-imidazo[1,2-b][1,2,4]triazine 
• 4512-05-4 N-(5,6-diphenyl-[1,2,4]triazin-3-yl)-diacetamide 
• 10243-70-6 2,3,6-triphenyl-imidazo[1,2-b][1,2,4]triazine 
• 70111-81-8 2,3,6,7-tetraphenyl-imidazo[1,2-b][1,2,4]triazine 
• 20375-99-9 4-amino-N-(5,6-diphenyl-[1,2,4]triazin-3-yl)-benzenesulfonamide 
• 61802-79-7 2,3-diphenyl-6-thiophen-2-yl-imidazo[1,2-b][1,2,4]triazine 
• 21134-91-8 5,6-diphenyl-1,2,4-triazine 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 
• 115125-27-4 2-methyl-5,6-diphenyl-1,2,4-triazin-3(2H)-imine hydriodide 
• 70111-77-2 2,3,6-Triphenyl-7-bromoimidazo<1,2-b>-1,2,4-triazine 
• 91028-81-8 2,3-Diphenyl-6-(4-bromophenyl)-7-bromoimidazo<1,2-b>-1,2,4-triazine 
• 107613-73-0 7-Butyl-6-hydroxy-2,3-diphenyl-pyrimido[1,2-b][1,2,4]triazin-8-one 
• 107613-77-4 7-Ethyl-6-hydroxy-2,3-diphenyl-pyrimido[1,2-b][1,2,4]triazin-8-one 
• 107613-78-5 7-Benzyl-6-hydroxy-2,3-diphenyl-pyrimido[1,2-b][1,2,4]triazin-8-one 

Relevant articles and documents

Synthesis and reactions of 1,2,4-triazine azides with triphenylphosphine, trialkyl phosphites and dialkyl phosphonates

3-Azido-5,6-diphenyl-1,2,4-triazine (1) and 3-azidophenanthro[9,10-e]-1,2,4-triazine (2) are synthesized in high yield (-75%), 1 and 2 react with triphenylphosphine to afford phosphazenes 5 and 6 with a covalent structure. Reactions of 1 and 2 with trialkyl phosphites 3b,c produce phosphazenes 7a,b and 8a,b which have the phosphonium dipolar ion structure, 1 reacts with diethyl phosphonate (4a) to give the phosphoramidate 10a, dissociating to the corresponding amine 11 on reaction with dimethyl phosphonate. Possible reaction mechanisms are proposed for the formation of the new adducts.

ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME

The present invention relates to a novel organic compound and an organic electroluminescent device using the same. An organic electroluminescent device is provided to improve luminous efficiency, driving voltage and lifetime by including an organic compound having excellent luminous efficiency, electron transporting capability, electrochemical stability, and thermal stability.

Synthesis, spectroscopic (UV-vis and GIAO NMR), crystallographic and theoretical studies of triazine heterocyclic derivatives

Abstract This work presents the synthesis and characterization of triazine heterocyclic derivatives. The spectroscopic properties like nuclear magnetic resonance [NMR, (1H and 13C)] were recorded in CDCl3 solution and Ultr

Discovery of 1,2,4-triazine derivatives as adenosine A2A antagonists using structure based drug design

Potent, ligand efficient, selective, and orally efficacious 1,2,4-triazine derivatives have been identified using structure based drug design approaches as antagonists of the adenosine A2A receptor. The X-ray crystal structures of compounds 4e and 4g bound to the GPCR illustrate that the molecules bind deeply inside the orthosteric binding cavity. In vivo pharmacokinetic and efficacy data for compound 4k are presented, demonstrating the potential of this series of compounds for the treatment of Parkinson's disease.

1,2,4-TRIAZINE-4-AMINE DERIVATIVES

According to the invention there is provided a compound of formula A1 which may be useful in the treatment of a condition or disorder ameliorated by the inhibition of the A1- A2b or, particularly, the A2a receptor wherein the compound of formula A1 has the structure, wherein, A represents Cy1 or HetA; Cy1 represents a 5- to 14-membered aromatic, fully saturated or partially unsaturated carbocyclic ring system comprising one, two or three rings, which Cy1 group is optionally substituted by one or more R4a substituents; HetA represents a 5- to 14-membered heterocyclic group that may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from O, S and N, which heterocyclic group may comprise one, two or three rings and which HetA group is optionally substituted by one or more R4b substituents; B represents a Cy2 or HetB; Cy2 represents a 3- to 10-membered aromatic, fully saturated or partially unsaturated carbocyclic ring system comprising one or two rings, which Cy2 group is optionally substituted by one or more R4c substituents; HetB represents a 3- to 10-membered heterocyclic group that may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from O, S and N, which heterocyclic group may comprise one or two rings and which HetB group is optionally substituted by one or more R4d substituents.

SN(ANRORC) MECHANISM IN AMINATION OF 3-X-5,6-DIPHENYL-1,2,4-TRIAZINES WITH AMIDE ION IN LIQUID AMMONIA

The reaction of 3-X-5,6-diphenyl-1,2,4-triazines, (X=SCH3, Cl, SO2CH3, N(CH3)3) with potassium amide in liquid ammonia was studied.It has been proved, using the corresponding (4-15N)-1,2,4-triazines, that all these compounds undergo substitution by amino group according to both SN(AE) and SN(ANRORC) processes.The reaction pathway was strongly influenced by the character of the leaving group.