21134-91-8Relevant academic research and scientific papers
Novel one pot synthesis of substituted 1,2,4-triazines
Nongkhlaw, Rishan Lang,Myrboh, Bekington
, p. 67 - 72 (2007/10/03)
Substituted-1,2,4-triazines were conveniently prepared in one pot by the condensation of amides and 1,2-diketones in presence of base, followed by cyclisation with hydrazine hydrate.
Deamination of 2-aminothiazoles and 3-amino-1,2,4-triazines with nitric oxide in the presence of a catalytic amount of oxygen
Itoh, Takashi,Matsuya, Yuji,Nagata, Kazuhiro,Ohsawa, Akio
, p. 1547 - 1549 (2007/10/03)
2-Aminothiazoles, 2-aminobenzazoles, and 3-amino-1,2,4-triazines were deaminated using nitric oxide (NO) in the presence of a catalytic amount of oxygen to afford corresponding unsubstituted heterocycles in good yields.
Synthesis of Isoquinolines by Cycloaddition of Arynes to 1,2,4-Triazines
Gonsalves, Antonio M. d'A. Rocha,Melo, Teresa M. V. D. Pinho e
, p. 6821 - 6826 (2007/10/02)
Benzyne has been generated from benzenediazonium-2-carboxylate in the presence of several 1,2,4-triazines 1 and isoquinolines 2 have been isolated in moderate yield. 1-Aminobenzotriazole was also used as the source of benzyne and isoquinolines were again isolated in moderate yield from these reactions. 4-Methylbenzyne, which was generated from 5-methylanthranilic acid, reacted unselectively with the triazines to give mixtures of 6- and 7-methylisoquinolines 3 and 4.On the other hand reactions of 3-methylbenzyne with the triazines 1d and 1e proceeded with high regioselectivity, giving only the 5-methylisoquinoline 5a and the 8-methylisoquinoline 6b, respectively.
The Configuration of 1,2-Diketone Hydrazone Oximes
Gnichtel, Horst,Toepper, Bernhard
, p. 1071 - 1074 (2007/10/02)
The configuration of 1,2-diketone (Z)-hydrazone (E)-oximes 3a-c was determined by ring closure with formaldehyde to 1,2,4-triazine 4-oxides 5a-c and the tautomeric 4-hydroxy-1,2,4-triazines 6a-c and by Beckmann reaction to 1,2,4 triazoles 8a-c.From benzil
STUDIES ON as-TRIAZINE DERIVATIVES. X. ADDITION REACTION OF PHENYLMAGNESIUM BROMIDE WITH 1,2,4-TRIAZINES
Konno, Shoetsu,Sagi, Mataichi,Yoshida, Nobuko,Yamanaka, Hiroshi
, p. 3111 - 3114 (2007/10/02)
The reaction of 1,2,4-triazine with phenylmagnesium bromide was investigated.Every position 3,5, and 6 in a 1,2,4-triazine ring is active in the addition reaction of Grignard reagents.Since 5-phenyl-1,2,4-triazine, 5,6-diphenyl-1,2,4-triazine, and 3,5,6-t
