4512-49-6Relevant academic research and scientific papers
PYRAZOLE DERIVATIVES AS SGC STIMULATORS
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Paragraph 00329, (2016/04/09)
There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Identification and design of a novel series of MGAT2 inhibitors
Barlind, Jonas G.,Buckett, Linda K.,Crosby, Sharon G.,Davidsson, ?jvind,Emten?s, Hans,Ertan, Anne,Jurva, Ulrik,Lemurell, Malin,Gutierrez, Pablo Morentin,Nilsson, Karolina,O'Mahony, Gavin,Petersson, Annika U.,Redzic, Alma,W?gberg, Fredrik,Yuan, Zhong-Qing
, p. 2721 - 2726 (2013/06/27)
[Acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome. In this Letter we report our discovery and optimisation of a novel series of MGAT2 inhibitors. The development of the SAR of the series and a detailed discussion around some key parameters monitored and addressed during the lead generation phase will be given. The in vivo results from an oral lipid tolerance test (OLTT) using the MGAT2 inhibitor (S)-10, shows a significant reduction (68% inhibition relative to nave, p 0.01) in plasma triacylglycerol (TAG) concentration.
