1431140-97-4

Basic information

• Product Name: C₁₉H₂₁N₃O₄S
• Synonyms: C₁₉H₂₁N₃O₄S
• CAS NO: 1431140-97-4
• Molecular Weight: 387.459
• Mol File: 1431140-97-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₁N₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₁N₃O₄S(1431140-97-4)
• EPA Substance Registry System: C₁₉H₂₁N₃O₄S(1431140-97-4)

Safety Data

• Hazardous Substances Data: 1431140-97-4(Hazardous Substances Data)

Upstream product

• 1444223-76-0 2-(2-aminobenzamido)-2-methylbutanoic acid 
• 1444223-90-8 2-methyl-2-(2-nitrobenzamido)butanoic acid 
• 1444223-97-5 methyl 2-methyl-2-(2-nitrobenzamido)butanoate 
• 156032-14-3 (±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride 
• 1431141-36-4 C₁₂H₁₃ClN₂O₄S 
• 100-46-9 benzylamine 
• 610-14-0 2-nitrobenzyl chloride 
• 1431141-26-2 C₁₂H₁₆N₂O₃ 
• 1431141-25-1 C₂₀H₂₂N₂O₅ 
• 1444224-07-0 C₁₃H₁₆FNO₃ 
• 4512-49-6 2-(((benzyloxy)carbonyl)amino)-2-methylbutanoic acid 
• 595-39-1 DL-isovaline 
• 1431141-33-1 3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 

Relevant articles and documents

Identification and design of a novel series of MGAT2 inhibitors

[Acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome. In this Letter we report our discovery and optimisation of a novel series of MGAT2 inhibitors. The development of the SAR of the series and a detailed discussion around some key parameters monitored and addressed during the lead generation phase will be given. The in vivo results from an oral lipid tolerance test (OLTT) using the MGAT2 inhibitor (S)-10, shows a significant reduction (68% inhibition relative to nave, p 0.01) in plasma triacylglycerol (TAG) concentration.