451466-79-8

Basic information

• Product Name: 8-Quinolinol, 5,6,7,8-tetrahydro-, (8S)- (9CI)
• Synonyms: 8-Quinolinol, 5,6,7,8-tetrahydro-, (8S)- (9CI);8-QUINOLINOL, 5,6,7,8-TETRAHYDRO-, (8S)-;(S)-5,6,7,8-tetrahydroquinolin-8-ol
• CAS NO: 451466-79-8
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: PYRIDINE;ALCOHOL
• Mol File: 451466-79-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Quinolinol, 5,6,7,8-tetrahydro-, (8S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Quinolinol, 5,6,7,8-tetrahydro-, (8S)- (9CI)(451466-79-8)
• EPA Substance Registry System: 8-Quinolinol, 5,6,7,8-tetrahydro-, (8S)- (9CI)(451466-79-8)

Safety Data

• Hazardous Substances Data: 451466-79-8(Hazardous Substances Data)

Upstream product

• 56826-69-8 5,6,7,8-tetrahydro-8-quinolinone 
• 14631-46-0 5,6,7,8-tetrahydroquinoline-8-ol 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Chiral amino-pyridine-phosphine tridentate ligand, manganese complex, and preparation method and application thereof

The invention discloses a chiral amino-pyridine-phosphine tridentate ligand, a manganese complex, and a preparation method and application thereof. The chiral amino-pyridine-phosphine tridentate ligand is shown as a formula II, and the manganese complex of the chiral amino-pyridine-phosphine tridentate ligand can be used for efficiently catalyzing and hydrogenating ketone compounds to prepare chiral alcohol compounds in a high enantioselectivity mode. The chiral amino-pyridine-phosphine tridentate ligand and the manganese complex are simple in synthesis process, good in stability, high in catalytic activity and mild in reaction conditions.

Asymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis

A series of methyl aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asymmetric reduction of heterocyclic ketones (S/C = 100-500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcohols are valuable building blocks in drug discovery or can be used as ligands in asymmetric catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations.

Kinetic resolution of pyridyl alcohols by Cu(II)(borabox)-catalyzed acylation

Kinetic resolution of pyridyl alcohols has been achieved using copper(II)(borabox)-catalyzed benzoylation. Selectivity factors (k rel) of up to 125 have been observed and application to the synthesis of chiral pyridyl phosphine ligands is descr