4515-89-3

Usage

Uses

Used in Flavor and Fragrance Industry:
Cyclopropanecarboxaldehyde, 1-methylis used as a flavoring agent for its strong, fruity odor, adding unique taste and aroma to food products.
Used in Perfume Production:
Cyclopropanecarboxaldehyde, 1-methylis utilized as a fragrance ingredient in the creation of various perfumes and consumer products, enhancing their scent profiles.
Used in Pharmaceutical Synthesis:
Methylcyclopropanecarboxaldehyde serves as a valuable building block in organic chemistry, playing a crucial role in the synthesis of various pharmaceuticals.
It is important to handle Cyclopropanecarboxaldehyde, 1-methylwith care due to its flammable nature and potential to cause irritation upon contact with skin or eyes.

Upstream product

• 10575-90-3 N-nitroso-N-cyclopropylurea 
• 75-07-0 acetaldehyde 
• 6206-25-3 methyl 1-methylcyclopropanecarboxylate 

Downstream Products

• 72646-47-0 3-(3-Isopropyl-phenyl)-1-(1-methyl-cyclopropyl)-propan-1-ol 
• 938058-08-3 Amino-(1-methyl-cyclopropyl)-acetic acid; hydrochloride 
• 951789-81-4 C₁₅H₂₁NO₃ 
• 139132-43-7 (+/-)-2-(1'-methylcyclopropyl)glycine 
• 173485-30-8 (+/-)-N-benzyloxycarbonyl-2-(1'-methylcyclopropyl)glycine 
• 259538-92-6 (2 R)-1-[(1-Methylcyclopropyl)methyl]-2-pyrrolidinecarboxamide 
• 1334675-14-7 (R)-2-((S)-2-hydroxy-1-phenylethylamino)-2-(1-methylcyclopropyl)acetic acid 
• 1334675-15-8 (R)-2-amino-2-(1-methylcyclopropyl)acetic acid hydrochloride 

Relevant academic research and scientific papers

Deamination Reactions, 42. Addition of Diazocyclopropanes to Carbonyl Compounds

Diazocyclopropanes (6, 38, 57) were generated in equilibrium with cyclopropanediazonium ions by base-induced cleavage of the analogous nitrosoureas in methanol.Efficient trapping of the diazocyclopropanes occurred in dilute solution with a slight excess of carbonyl compounds.The reactivity of the resulting 1-(α-hydroxyalkyl)cyclopropanediazonium ions (10) depended strongly on the α-substituents.Pinacol rearrangements predominated with aldehyde adducts, the migratory aptitudes being H > Ph > CH3.These 1,2-shifts are thought to proceed with inversion at the terminus - the preferred exo-attack of acetaldehyde at 7-diazonorcarane (38) led to the endo-ketone 40.The major product derived from the acetone adduct 22 was the epoxide 26 whose reaction(s) with metanol were also examined.The intramolecular addition of 8-diazobicyclooctan-4-one (57) gave rise to 6-methoxybicyclooct-4-en-1-ol (60).Due to steric constraints, the intermediate 58 underwent exclusive cyclopropyl-allyl transformations (otherwise a minor reaction).

Conformational Analysis of the Cyclopropylacyl, Oxiranylacyl, and Aziridinylacyl Radicals by Electron Spin Resonance Spectroscopy

A series of ring-substituted cyclopropylacyl, oxiran-2-ylacyl, and aziridin-2-ylacyl radicals have been prepared principally by the reaction of photolytically generated t-butoxyl radicals with the corresponding aldehydes.The e.s.r. spectra show that the cyclopropylacyl ?-radicals exist in s-cis- and s-trans-conformations of approximately equal stability, in which the plane of the acyl group bisects the ring (as it does in the parent aldehyde), and simulation of the spectra through the region of intermediate rates of exchange show that the barrier to rotation is ca. 17.5 kJ*mol-1.The behaviour of the trans-2-ethoxycarbonylcyclopropylacyl and 2,2-dimethylcyclopropylacyl radicals is similar.The oxiranylacyl and trans-3-methyloxiranylacyl radicals exist in the same two conformations with a rather lower barrier, and the N-alkylaziridinylacyl radicals appear to have a lower barrier still.