1-Methylcyclopropane-1-carbaldehyde

Base Information

• Chemical Name: 1-Methylcyclopropane-1-carbaldehyde
• CAS No.: 4515-89-3
• Molecular Formula: C5H8O
• Molecular Weight: 84.1179
• European Community (EC) Number: 818-532-4
• Nikkaji Number: J488.671B
• Mol file: 4515-89-3.mol

Synonyms:4515-89-3;1-methylcyclopropane-1-carbaldehyde;1-methylcyclopropanecarbaldehyde;Cyclopropanecarboxaldehyde, 1-methyl-;methylcyclopropanecarbaldehyde;1-Methyl-cyclopropanecarbaldehyde;DOJZSEYEQKWUSI-UHFFFAOYSA-N;MFCD20040089;AKOS023427483;PB42841;PS-16284;SY310800;CS-0091473;FT-0763226;EN300-182105;A937190;Z1263714317

Chemical Property of 1-Methylcyclopropane-1-carbaldehyde

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 84.057514874
• Heavy Atom Count: 6
• Complexity: 72

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(CC1)C=O

Technology Process of 1-Methylcyclopropane-1-carbaldehyde

There total 2 articles about 1-Methylcyclopropane-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-nitroso-N-cyclopropylurea (10575-90-3) + acetaldehyde (75-07-0,9002-91-9) → Cyclopropyl methyl ketone (765-43-5) + methylallylether (627-40-7) + cyclopropyl methyl ether (540-47-6) + 1-methylcyclopropanecarbaldehyde (4515-89-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 3h; Yield given. Yields of byproduct given;

Reference yield:

methyl 1-methylcyclopropanecarboxylate (6206-25-3) → 1-methylcyclopropanecarbaldehyde (4515-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium hydride

2: chromium(VI) oxide / pyridine

With chromium(VI) oxide; lithium aluminium tetrahydride; In pyridine;

Reference yield: 85.0%

1-methylcyclopropanecarbaldehyde (4515-89-3) + (-)-alpha-Methyltryptamine (7795-52-0,304-54-1) → (R)-1-(1H-indol-3-yl)-N-((1-methylcyclopropyl)methyl)propan-2-amine

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 12.5h;

upstream raw materials:

N-nitroso-N-cyclopropylurea

acetaldehyde

methyl 1-methylcyclopropanecarboxylate

Downstream raw materials:

3-(3-Isopropyl-phenyl)-1-(1-methyl-cyclopropyl)-propan-1-ol

Amino-(1-methyl-cyclopropyl)-acetic acid; hydrochloride

4-(1-methylcyclopropyl)-3(E)-buten-2-one

C₁₅H₂₁NO₃