45162-48-9

Basic information

• Product Name: Dodecanoic acid, 3-hydroxy-, (3S)-
• CAS NO: 45162-48-9
• Molecular Formula: C12H24O3
• Molecular Weight: 216.321
• Mol File: 45162-48-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Dodecanoic acid, 3-hydroxy-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Dodecanoic acid, 3-hydroxy-, (3S)-(45162-48-9)
• EPA Substance Registry System: Dodecanoic acid, 3-hydroxy-, (3S)-(45162-48-9)

Safety Data

• Hazardous Substances Data: 45162-48-9(Hazardous Substances Data)

Upstream product

• 76835-64-8 methyl 3-oxododecanoate 
• 112-31-2 caprinaldehyde 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 96-32-2 bromoacetic acid methyl ester 
• 117951-87-8 1-tridecen-4-ol 
• 933486-31-8 C₁₂H₂₄O₂ 
• 182359-65-5 5-decanoyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 112-13-0 n-decanoyl chloride 
• 183613-15-2 3-hydroxydodecanoic acid ethyl ester 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 142-61-0 Hexanoyl chloride 

Downstream Products

• 53089-84-2 tert.-Butyl-O-(N-benzyloxycarbonyl-L-valyl)-L-3-hydroxydodecanoat 

Relevant articles and documents

The metabolism of unsaturated fatty acids. IV. On the beta-oxidation of mono-and polyene-fatty acids. Chemical syntheses of intermediary products

-

The Preparation of Optically Pure 3-Hydroxyalkanoic Acid. The Enantioface-differentiating Hydrogenation of the C=O Double Bond with Modified Raney Nickel. XXXVII

The enantioface-differentiating hydrogenation of methyl 3-oxoalkanoate (CH3(CH2)nCOCH2COOCH3, n=0, 6, 8, 10, 12) over the (R,R)-tartaric acid-NaBr-modified Raney nickel catalyst ((R,R)-TA-NaBr-MRNi) gave methyl (R)-3-hydroxyalkanoate (CH3(CH2)nCH(OH)CH2COOCH3, n=0, 6, 8, 10, 12) in an average optical yield of 85percent.After the methyl ester had been converted to dicyclohexylammonium salt of 3-hydroxyalkanoic acid, the salt was recrystallized three times from acetonitrile and then treated with acid to give optically pure (R)-3-hydroxyalkanoic acid (CH3(CH2)nCH(OH)CH2COOH, n=0, 6, 8, 10, 12) in a reasonable yield.From the hydrogenation product with (S,S)-TA-NaBr-MRNi, optically pure (S)-3-hydroxyalkanoic acid was obtained by the same process as above.