4519-48-6

Basic information

• Product Name: methyl 2-bromo-2-chloro-3-(4-methylphenyl)propanoate
• Synonyms: methyl 2-bromo-2-chloro-3-(4-methylphenyl)propanoate
• CAS NO: 4519-48-6
• Molecular Weight: 291.572
• Mol File: 4519-48-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-bromo-2-chloro-3-(4-methylphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-bromo-2-chloro-3-(4-methylphenyl)propanoate(4519-48-6)
• EPA Substance Registry System: methyl 2-bromo-2-chloro-3-(4-methylphenyl)propanoate(4519-48-6)

Safety Data

• Hazardous Substances Data: 4519-48-6(Hazardous Substances Data)

Upstream product

• 80-63-7 methyl 2-chloroacrylate 
• 106-49-0 p-toluidine 
• 4519-46-4 methyl 2-bromoacrylate 

Downstream Products

• 144677-23-6 methyl 3-hydroxy-5-(4-methylphenyl)thiophene-2-carboxylate 
• 14737-96-3 methyl 2-chloro-3-(p-tolyl)acrylate 
• 1552-73-4 2-Chlor-3-p-tolyl-acrylsaeure 

Relevant articles and documents

Bromoarylation of Methyl 2-Chloroacrylate under Meerwein Conditions for the Synthesis of Substituted 3-Hydroxythiophenes

Methyl 3-aryl-2-bromo-2-chloropropanoates can be prepared by Meerwein reaction from methyl 2-chloroacrylate and various arenediazonium salts under copper(II) bromide catalysis. The resulting readily available compounds were used as starting materials in reactions with substituted methanethiols for the construction of substituted 3-hydroxythiophenes which have not yet been accessible by other routes. Structural variety of the obtained 2-substituted 5-aryl-3-hydroxythiophenes has been achieved due to a wide range of available starting materials, including both anilines and thiols.