4519-48-6Relevant academic research and scientific papers
Bromoarylation of Methyl 2-Chloroacrylate under Meerwein Conditions for the Synthesis of Substituted 3-Hydroxythiophenes
Ostapiuk, Yurii V.,Shehedyn, Maksym,Barabash, Oksana V.,Demydchuk, Bohdan,Batsyts, Sviatoslav,Herzberger, Colin,Schmidt, Andreas
, p. 732 - 740 (2021/11/20)
Methyl 3-aryl-2-bromo-2-chloropropanoates can be prepared by Meerwein reaction from methyl 2-chloroacrylate and various arenediazonium salts under copper(II) bromide catalysis. The resulting readily available compounds were used as starting materials in reactions with substituted methanethiols for the construction of substituted 3-hydroxythiophenes which have not yet been accessible by other routes. Structural variety of the obtained 2-substituted 5-aryl-3-hydroxythiophenes has been achieved due to a wide range of available starting materials, including both anilines and thiols.
