632625-93-5Relevant academic research and scientific papers
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists
Hall, Adrian,Atkinson, Stephen,Brown, Susan H.,Chessell, Iain P.,Chowdhury, Anita,Giblin, Gerard M.P.,Goldsmith, Paul,Healy, Mark P.,Jandu, Karamjit S.,Johnson, Matthew R.,Michel, Anton D.,Naylor, Alan,Sweeting, Jennifer A.
, p. 1200 - 1205 (2007/10/03)
Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high bi
CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives
Wei, Robert G.,Arnaiz, Damian O.,Chou, Yuo-Ling,Davey, Dave,Dunning, Laura,Lee, Wheeseong,Lu, Shou-Fu,Onuffer, James,Ye, Bin,Phillips, Gary
, p. 231 - 234 (2007/10/03)
High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist. Initial modifications of the guanylhydrazone series indicated that substitution of the benzyl group at the para-position was well tolerated. Substitution at the 5-position of the central phenyl ring was critical for potency. Replacement of the guanylhydrazone group led to the discovery of a novel series of CCR5 antagonists.
