452-85-7

Usage

Chemical Properties

Colorless transparent liquid

InChI:InChI=1/C7H7FO/c1-5-2-3-6(8)4-7(5)9/h2-4,9H,1H3

Upstream product

• 452-73-3 2-chloro-4-fluorotoluene 
• 352-32-9 p-fluorotoluene 
• 367-29-3 3-fluoro-6-methylaniline 

Downstream Products

• 395-95-9 2-(5-fluoro-2-methyl-phenoxy)-benzoic acid 
• 95729-22-9 1-Fluoro-3-methoxy-4-methylbenzene 
• 1494-57-1 2-(5-fluoro-2-methyl-phenoxy)-benzoic acid methyl ester 
• 668-64-4 1-fluoro-9-oxo-xanthene-4-carboxylic acid-(4-nitro-benzyl ester) 
• 915409-67-5 C₁₃H₂₁FOSi 
• 929529-23-7 5-(5-fluoro-2-methylphenoxymethyl)-6-(2-methoxy-4-methoxymethoxyphenyl)-2,2,4-trimethyl-1,2-dihydroquinoline 
• 1072003-93-0 tert-butyl [5-(5-fluoro-2-methylphenoxy)-2-nitrophenyl]methylcarbamate 
• 949891-80-9 7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one 
• 1204517-75-8 C₁₂H₁₅FO₂ 
• 1021491-20-2 2-fluoro-4-hydroxy-5-methylbenzaldehyde 
• 1257323-62-8 C₃₂H₃₄FN₃O₅ 
• 1175014-74-0 4-[2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1345250-80-7 C₂₄H₂₃F₂N₅O₂ 
• 1345251-82-2 C₁₈H₁₄F₂N₄O 

Relevant academic research and scientific papers

Synthesis method of substituted phenol

The invention provides a synthesis method of substituted phenol. The target product substituted phenol is prepared by taking substituted benzene as an initial raw material, and the whole synthetic process is high in selectivity, high in yield, convenient to operate and high in atom economy.

Pd2dba3/Bippyphos: A robust catalyst system for the hydroxylation of aryl halides with broad substrate scope

A mixture of tris(dibenzylideneacetone)dipalladium(0) (Pd 2dba3) and 5-(di-tert-butylphosphino)-1′,3′, 5′-triphenyl-1′H-[1,4′]bipyrazole (Bippyphos) is shown to be a robust and efficient catalyst system for the hydroxylation of structurally diverse (hetero)aryl halides under mild conditions and with broad substrate scope. Included in this reactivity survey is the successful synthesis of substituted benzofurans and related heteroatomic derivatives, which are formed via the hydroxylation of 2-haloalkynylarenes. Notably, a significant number of the reactions reported herein proceed at room temperature, and we have demonstrated that it is possible to conduct reactions on the benchtop under air using unpurified solvents with negligible loss in reactivity versus related transformations conducted under inert atmosphere conditions. We also report herein the first crystallographically characterized (Bippyphos)Pd(II) complex, which confirms the ability of this synthetically useful ligand to adopt a bidentate binding motif in a manner similar to Buchwald's biarylphosphine ligand class. Copyright

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Compounds that modulate PPAR activity and methods of preparation

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.