452085-30-2

Upstream product

• 142945-22-0 (2S,3R)-6-(benzyloxy)-2-methylhexane-1,3-diol 
• 452085-14-2 (4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane 
• 452085-24-4 (2S,3R,4S,5R)-8-Benzyloxy-2-{(2S,5R)-5-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-yl}-4-methyl-5-triethylsilanyloxy-octan-3-ol 
• 452085-21-1 [(S)-2-((2R,5S)-5-{(R)-[(4S,5R,6R)-6-(3-Benzyloxy-propyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-iodo-methyl}-tetrahydro-furan-2-yl)-propoxy]-tert-butyl-diphenyl-silane 
• 1026870-22-3 tert-Butyl-[(S)-2-((2R,5S)-5-{(R)-1-[(4R,5R,6R)-6-(3-iodo-propyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-ethyl}-tetrahydro-furan-2-yl)-propoxy]-diphenyl-silane 
• 452085-16-4 (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[(R)-4-benzyloxy-1-((S)-2-hydroxy-1-methyl-ethyl)-butyl] ester 
• 452085-20-0 (3R,4R,5R)-8-Benzyloxy-4-methyl-oct-1-ene-3,5-diol 

Downstream Products

• 452085-31-3 (S)-1-[(2S,5R)-5-((1S,2S,3S)-3-{(2S,5R)-5-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-yl}-2-hydroxy-1-methyl-butyl)-tetrahydro-furan-2-yl]-pentan-2-ol 
• 452085-32-4 ((S)-2-{(2R,5S)-5-[(1R,2S,3R)-3-[(2R,5S)-5-((R)-2-Azido-pentyl)-tetrahydro-furan-2-yl]-2-(4-methoxy-benzyloxy)-1-methyl-butyl]-tetrahydro-furan-2-yl}-propoxy)-tert-butyl-diphenyl-silane 

Relevant academic research and scientific papers

A stereocontrolled synthetic route to the C1-C18 subunit of pamamycin-607

The C1-C18 subunit 2 of the 16-membered macrodiolide pamamycin-607 has been synthesized stereoselectively using the Ag2CO3-mediated intramolecular iodoetherification for the two cis-2,5-disubstituted tetrahydrofurans, crotylation and cuprate epoxide opening for the hydroxyl and methyl substituents.