452333-53-8 Usage
Uses
Used in Pharmaceutical Industry:
Pyridine, 2-ethynyl-5-nitro(9CI) serves as a crucial building block in the synthesis of a variety of drugs and biologically active compounds. Its distinctive molecular structure allows for the creation of new pharmaceutical agents that can address specific medical needs.
Used in Research Laboratories:
In research settings, Pyridine, 2-ethynyl-5-nitro- (9CI) acts as a valuable reagent in organic synthesis. Its ethynyl and nitro groups facilitate various chemical reactions that are essential for the development of new organic compounds and materials.
Used in Agricultural Chemicals Production:
Pyridine, 2-ethynyl-5-nitro(9CI) also finds application as a precursor in the production of agricultural chemicals, including insecticides. Its role in these products is instrumental in enhancing crop protection and contributing to more effective and targeted pest control strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 452333-53-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,2,3,3 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 452333-53:
(8*4)+(7*5)+(6*2)+(5*3)+(4*3)+(3*3)+(2*5)+(1*3)=128
128 % 10 = 8
So 452333-53-8 is a valid CAS Registry Number.
452333-53-8Relevant academic research and scientific papers
Metal-free synthesis of 2-alkenyl/alkynyl-5-nitropyridines using a three-component ring transformation
Le, Song Thi,Asahara, Haruyasu,Nishiwaki, Nagatoshi
supporting information, p. 776 - 778 (2015/06/22)
A metal-free, facile, and efficient protocol for synthesizing a series of 2-alkenyl/alkynyl-5-nitropyridines was developed by using a three-component ring transformation of 1-methyl-3,5- dinitro-2-pyridone with α,β-unsaturated ketones and ammonium acetate
Nitropyridines: X.* Palladium-catalyzed cross-coupling of 2-bromo-5-nitropyridine with terminal acetylenes
Sagitullina,Vorontsova,Garkushenko,Poendaev,Sagitullin
experimental part, p. 1830 - 1834 (2011/04/15)
Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes. Desilylation, oxidative decarbonylation, and the retro-Favorskii reaction of the cross-coupling products of 2-bromo-5-nitropyridine with trimethylsilylacetylene, prop-2-ynyl alcohol, and 2-methylbut-3-yn-2-ol, respectively, gave 2-ethynyl-5-nitropyridine. The hydration of 2-ethynyl-5-nitropyridine and 5-nitro-2-(phenylethynyl)pyridine according to Kucherov afforded 2-acetyl-5-nitropyridine and 5-nitro-2-phenacylpyridine, respectively. Pleiades Publishing, Ltd., 2010.
