452335-63-6Relevant academic research and scientific papers
Horner-Wadsworth-Emmons modification for Ramirez gem-dibromoolefination of aldehydes and ketones using P(Oi-Pr)3
Fang, Yuan-Qing,Lifchits, Olga,Lautens, Mark
, p. 413 - 417 (2008)
A simple procedure for the use of triisopropylphosphite in the Ramirez olefination is described. This reagent is equally or more reactive than PPh 3 toward aldehydes and ketones in the gem-dibromoolefination of aldehydes and ketones. Under the
TRIPHENYLETHYLENE COMPOUNDS AND USES THEREOF
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Paragraph 0151-0152, (2017/06/19)
Triphenylethylene compounds as dual aromatase inhibitors and selective estrogen receptors modulators are described. Also described are methods for treating patients of breast cancers, and patients of breast cancer comorbid with osteoporosis, using the des
A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β
Zhao, Li-Ming,Jin, Hai-Shan,Liu, Jinzhong,Skaar, Todd C.,Ipe, Joseph,Lv, Wei,Flockhart, David A.,Cushman, Mark
, p. 5400 - 5409 (2016/10/24)
The design and synthesis of dual aromatase inhibitors/selective estrogen receptor modulators (AI/SERMs) is an attractive strategy for the discovery of new breast cancer therapeutic agents. Previous efforts led to the preparation of norendoxifen (4) deriva
Olefination of aromatic ketones: Synthesis of mono- and dihaloalkenes
Korotchenko, Vasily N.,Shastin, Alexey V.,Nenajdenko, Valentine G.,Balenkova, Elisabeth S.
, p. 883 - 887 (2007/10/03)
A new simple and efficient transformation of various aromatic ketones to the corresponding halo (dihalo) alkenes is described. The reaction proceeds under mild conditions to give the target products in good yields.
