452341-55-8Relevant academic research and scientific papers
Asymmetric Synthesis of Fused Bicyclic N,O- and O,O-Acetals via Cascade Reaction by Gold(I)/N,N′-Dioxide-Nickel(II) Bimetallic Relay Catalysis
Hu, Bowen,Li, Jun,Cao, Weidi,Lin, Qianchi,Yang, Jian,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
, p. 2831 - 2835 (2018)
An efficient catalytic asymmetric cyclization/inverse-electron-demand hetero-Diels-Alder cascade reaction of β,γ-unsaturated α-ketoesters with alkyl amides or alcohols were accomplished. The process was based on the utilization bimetallic catalyst system with achiral gold(I) catalyst and chiral N,N′-dioxide/Ni(II) catalyst, delivering a variety of fused bicyclic N,O-acetals or O,O-acetals in up to 99% yield and 99% ee with >19:1 dr under mild reaction conditions. Based on the control experiments and previous studies, a possible reaction pathway of bimetallic relay catalysis cascade reactions was presented. (Figure presented.).
A General Protocol for Robust Sonogashira Reactions in Micellar Medium
Jakobi, Markus,Gallou, Fabrice,Sparr, Christof,Parmentier, Michael
, (2019/03/13)
A robust and general protocol for a sustainable copper-free Sonogashira cross coupling under micellar aqueous reaction conditions with high turnover was developed. By using the commercially available catalyst CataCXium A Pd G3 and THF as co-solvent, vario
Rhodium(III)-catalyzed oxidative bicyclization of 4-arylbut-3-yn-1-amines with internal alkynes through C-H functionalization
Pi, Rui,Zhou, Ming-Bo,Yang, Yuan,Gao, Cai,Song, Ren-Jie,Li, Jin-Heng
supporting information, p. 13550 - 13553 (2015/09/01)
A new Rh(III)-catalyzed oxidative bicyclization through C-H functionalization is presented. This reaction allows the selective assembly of diverse benzo[g]indoles from 4-arylbut-3-yn-1-amines and internal alkynes via a sequence of aromatic C(sp2)-H functionalization, cyclodimerization and nucleophilic cyclization.
AMINO-5-[4-(DIFLUOROMETHOXY)-PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
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Page/Page column 25, (2008/06/13)
The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
