452342-37-9

Basic information

• Product Name: GW-6604
• Synonyms: GW-6604;2-Phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine
• CAS NO: 452342-37-9
• Molecular Formula: C19H14N4
• Molecular Weight: 298.34126
• Mol File: 452342-37-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 147 °C(Solv: dichloromethane (75-09-2); pentane (109-66-0))
• Boiling Point: 505.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.226±0.06 g/cm3(Predicted)
• PKA: 8.80±0.50(Predicted)
• CAS DataBase Reference: GW-6604(CAS DataBase Reference)
• NIST Chemistry Reference: GW-6604(452342-37-9)
• EPA Substance Registry System: GW-6604(452342-37-9)

Safety Data

• Hazardous Substances Data: 452342-37-9(Hazardous Substances Data)

Usage

General Description

GW-6604 is a chemical compound that belongs to the class of benzenesulfonamides and is categorized as a selective EP4 antagonist. It has been studied for its potential therapeutic applications in the treatment of inflammatory and autoimmune diseases. GW-6604 has demonstrated promising results in preclinical studies for its ability to inhibit the prostaglandin E2 receptor EP4, which plays a significant role in the regulation of immune and inflammatory responses. Its specific mode of action makes it a potential candidate for the development of novel drugs to target EP4-mediated pathways and alleviate the symptoms of various inflammatory conditions. However, further research is needed to fully understand its mechanisms and potential uses in clinical settings.

Upstream product

• 446852-65-9 2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one 
• 446880-81-5 2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine 
• 446880-83-7 2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine 
• 2524-52-9 ethyl-2-picolinate 
• 1333492-61-7 2-phenyl-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine 
• 98-80-6 phenylboronic acid 
• 3475-21-6 4-methyl-2-phenylpyridine 
• 4926-28-7 2-Bromo-4-picoline 
• 452343-02-1 2-(2-phenylpyridin-4-yl)-1-(pyridin-2-yl)ethanone 

Relevant articles and documents

2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling

Novel inhibitors of TGF-β1 and activin A signalling based on a 2-aryl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine pharmacophore have been synthesised. Compounds containing phenyl or aromatic nitrogen heterocycle substituents inhibited both types of signalling with HEK-293T cells in culture, with a selectivity preference for TGF-β1. Synthetic compounds containing pyridin-3-yl, pyrazol-4-yl, pyrazol-1-yl or 1H-imidazoyl-1-yl substituents exhibited structural and functional attributes suitable for further investigation related to the development of more potent TGF-β inhibitors.

Pyrazole derivatives against tgf overexpression

Therapeutically active pyrazole derivatives of formula (I) wherein R1-R3 are as defined in the specification, processes for the preparation thereof, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterised by overexpression of transforming growth factor β (TGF-β), and pharmaceutical compositions for use in such therapy, Formula (I)