452342-99-3

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 113170-67-5 (4-methyl-2-pyridyl)magnesium bromide 
• 3678-62-4 2-chloro-4-picoline 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 4926-28-7 2-Bromo-4-picoline 

Downstream Products

• 452343-03-2 2-{2-[4-(trifluoromethyl)phenyl]pyridin-4-yl}-1-(pyridin-2-yl)ethanone 
• 884600-79-7 methyl {2-[4-(trifluoromethyl)phenyl]-4-pyridinyl}acetate 

Relevant academic research and scientific papers

Visible Light Induced Rhodium(I)-Catalyzed C?H Borylation

An efficient visible light induced rhodium(I)-catalyzed regioselective borylation of aromatic C?H bonds is reported. The photocatalytic system is based on a single NHC?RhI complex capable of both harvesting visible light and enabling the bond breaking/forming at room temperature. The chelating nature of the NHC-carboxylate ligand was critical to ensure the stability of the RhI complex and to provide excellent photocatalytic activities. Experimental mechanistic studies evidenced a photooxidative ortho C?H bond addition upon irradiation with blue LEDs, leading to a cyclometalated RhIII-hydride intermediate.

New blue phosphorescent iridium complexes containing phenylpyridine and triazole ligands: Synthesis and luminescence studies

The synthesis and luminescence of iridium(III) complexes containing new phenylpyridine (C∧N) ligands, 4-Me-4'-F-ppy, 4-Me-4'-CF3-ppy and 4-OMe-4'-CF3-ppy, were studied. These ligands were designed for development of the blue light-em

Piperidine-derived γ-secretase modulators

This Letter details the SAR of a novel series of piperidine-derived γ-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42, increase Aβ38 and have no effect on Aβ40 levels.

Fluorinated piperidine acetic acids as γ-secretase modulators

We report herein a novel series of difluoropiperidine acetic acids as modulators of γ-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective β-difluorination with Selectfluor. Compounds 1f and 2c were selec

Kumada-corriu cross-couplings with 2-pyridyl grignard reagents

Chemical Equation Presentation SPOs meet the challenge: A palladium complex derived from air- and moisture-stable secondary phosphine oxide (SPO) (1-Ad)2P(O)H enables general cross-coupling reactions of challenging electron-deficient 2-pyridyl Grignard reagents with ample scope (see scheme)

Palladium-catalyzed cross-coupling reactions of 2-pyridylborates with air-stable HASPO religands

A novel, air-stable TADDOLP(O)H derivative bearing electron-withdrawing substituents allows for efficient Suzuki-Miyaura cross-couplings with challenging electron-deficient 2-pyr-idylborates as nucleophiles.

PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA

Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions.

The new iridium(III) pyridyltetrazolate complexes for blue phosphorescence

A series of new blue-phosphorescent iridium complexes containing phenypyridine (ppy) derivatives and pyridyltetrazole were synthesized and their photophysical and electroluminescent properties were investigated. In the complex, the phenyl moiety which is

SILYLATED PIPERIDINE DERIVATIVES

Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of A?(1-42) and hence find use in treatment of Alzheimer's disease and related conditions.

PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE

Compounds of formula (I) modulate the activity of gamma secretase and hence find use in treatment or prevention of Alzheimer's disease and related conditions.