4526-87-8

Upstream product

• 39552-95-9 N-(N-benzyloxycarbonyl-L-α-aspartyl)-glycine ethyl ester 
• 98690-54-1 Z-Asparagin-thiophenylester 
• 623-33-6 glycine ethyl ester hydrochloride 
• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 
• 77511-21-8 (S)-2-Benzyloxycarbonylamino-3-carbamoyl-propionatetetrabutyl-ammonium; 
• 459-73-4 GlyOEt*HCl 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 2949-22-6 Glycine ethyl ester isocyanate 
• 589-57-1 diethyl phosphorylchloridite 
• 71260-62-3 toluene-4-sulfonic acid salt of ethyl glycinate 

Relevant academic research and scientific papers

ONE-POT CYCLIZATION OF A PEPTIDE BY THE USE OF (5-NITROPYRIDYL)DIPHENYL PHOSPHINATE: THE SYNTHESIS OF CYCLIC DECAPEPTIDE GRAMICIDIN S

One-pot synthesis of gramicidin S, cyclic decapeptide, was successfully achieved by treatment of the corresponding linear decapeptide with (5-nitropyridyl)diphenyl phosphinate, a new condensing reagent, in pyridine.Similarly, the phosphinic ester can be successfully employed in the Young test as well as syntheses of dipeptides.

PEPTIDE SYNTHESIS BY USING PHENYLPHOSPHONIC ESTER AS A COUPLING REAGENT

Synthesis of peptides containing various functions was efficiently accomplished by treatment of the tetrabutylammonium salts of N-protected amino acids (or peptides) with amino acid esters in the presence of bis(o- or p-nitrophenyl) phenylphosphonate.Synthesis of leucine-enkephalin was successfully achieved by the above method employing a (3+2) or (4+1) fragment coupling approach.