452897-59-5

Upstream product

• 3157-65-1 N-(p-chlorobenzylidene)-p-toluenesulfonamide 
• 153942-69-9 3-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-indole 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 40899-73-8 N-tert-butyldimethylsilylindole 
• 120-72-9 indole 

Downstream Products

• 568588-93-2 [[[1-(tert-butyldimethylsilyl)-1H-indol-3-yl](4-chlorophenyl)methyl]-(toluene-4-sulfonyl)amino]acetic acid ethyl ester 
• 568589-01-5 1-(4-chlorophenyl)-2-(toluene-4-sulfonyl)-1,2,3,5-tetrahydropyrido[4,3-b]indol-4-one 

Relevant academic research and scientific papers

Synthesized γ-carbolines

The present invention concerns the compounds of the formula: and the prodrug and salts thereof, wherein R may be a hydroxyl or other pendent group and Ar is an aryl. The compositions may be adapted for the treatment of neurodegenerative diseases. Further,

Syntheses of functionalized 1,4-disubstituted γ-carbolines

We report the complete synthesis of a variety of 1,4-disubstituted γ-carbolines. These compounds are of particular interest for their involvement in many biological processes and are believed to possess various medicinal activities. A large number of N-to

Synthesis of 3-[(1-aryl)aminomethyl]indoles

We report the novel synthesis of various highly functionalized 3-arylaminomethyl indoles. This synthetic approach makes use of the directing ability of a bulky tertbutyldimethylsilyl-protecting group, which directs the condensation of an array of aromatic tosylaldimines specifically into the 3-position of the indole nucleus. The reactions, which occur under relatively mild conditions, afford the desired products in moderate yields. Prior to selective cleavage of the protecting group, the functionalized protected indoles also serve as attractive substrates for many future organic transformations.