452897-59-5

Basic information

• Product Name: N-[[1-(tert-butyldimethylsilanyl)-1H-indol-3-yl]-(4-chlorophenyl)methyl]-4-methylbenzenesulfonamide
• Synonyms: N-[[1-(tert-butyldimethylsilanyl)-1H-indol-3-yl]-(4-chlorophenyl)methyl]-4-methylbenzenesulfonamide
• CAS NO: 452897-59-5
• Molecular Weight: 525.187
• Mol File: 452897-59-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[[1-(tert-butyldimethylsilanyl)-1H-indol-3-yl]-(4-chlorophenyl)methyl]-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[[1-(tert-butyldimethylsilanyl)-1H-indol-3-yl]-(4-chlorophenyl)methyl]-4-methylbenzenesulfonamide(452897-59-5)
• EPA Substance Registry System: N-[[1-(tert-butyldimethylsilanyl)-1H-indol-3-yl]-(4-chlorophenyl)methyl]-4-methylbenzenesulfonamide(452897-59-5)

Safety Data

• Hazardous Substances Data: 452897-59-5(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 3157-65-1 N-(p-chlorobenzylidene)-p-toluenesulfonamide 
• 153942-69-9 3-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-indole 
• 40899-73-8 N-tert-butyldimethylsilylindole 
• 120-72-9 indole 

Downstream Products

• 568589-01-5 1-(4-chlorophenyl)-2-(toluene-4-sulfonyl)-1,2,3,5-tetrahydropyrido[4,3-b]indol-4-one 
• 568588-93-2 [[[1-(tert-butyldimethylsilyl)-1H-indol-3-yl](4-chlorophenyl)methyl]-(toluene-4-sulfonyl)amino]acetic acid ethyl ester 

Relevant articles and documents

Synthesized γ-carbolines

The present invention concerns the compounds of the formula: and the prodrug and salts thereof, wherein R may be a hydroxyl or other pendent group and Ar is an aryl. The compositions may be adapted for the treatment of neurodegenerative diseases. Further,

Synthesis of 3-[(1-aryl)aminomethyl]indoles

We report the novel synthesis of various highly functionalized 3-arylaminomethyl indoles. This synthetic approach makes use of the directing ability of a bulky tertbutyldimethylsilyl-protecting group, which directs the condensation of an array of aromatic tosylaldimines specifically into the 3-position of the indole nucleus. The reactions, which occur under relatively mild conditions, afford the desired products in moderate yields. Prior to selective cleavage of the protecting group, the functionalized protected indoles also serve as attractive substrates for many future organic transformations.