452956-92-2

Upstream product

• 1026057-88-4 (S)-2-((4S,5S,6R)-2,2,5-Trimethyl-6-tridecyl-[1,3]dioxan-4-yl)-propan-1-ol 
• 1613724-98-3 C₂₉H₃₈N₂O₇ 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 132090-11-0 N-Boc-O-Bn-L-Ser allyl ester 
• 1613725-00-0 C₂₆H₅₄O₃Si 
• 1613724-73-4 ethyl (2E,4R,5R)-5-hydroxy-2,4-dimethyloctadec-2-enoate 
• 1613724-97-2 C₁₇H₃₄O₂ 
• 1613724-75-6 (2S,3R)-2-methyl-3-[(trimethylsilyl)oxy]hexadecanal 
• 124-25-4 myristylaldehyde 
• 1613724-74-5 [(3R)-2-methyl-3-tridecyloxiran-2-yl]methanol 
• 452956-88-6 prop-2-en-1-yl (5R,6R,7R,8R,11S,14S,17S)-14-[1-(benzyloxy)ethyl]-17-[(benzyloxy)methyl]-7-hydroxy-2,2,3,3,6,8-hexamethyl-9,12,15-trioxo-11-(propan-2-yl)-5-tridecyl-4-oxa-10,13,16-triaza-3-silaoctadecan-18-oate 
• 478690-77-6 ethyl (2E)-2-methylhexadec-2-enoate 
• 452956-86-4 prop-2-en-1-yl (6S)-9-[ (1R)-1-(benzyloxy)ethyl]-12-[(benzyloxy)methyl]-2,2-dimethyl-4,7,10-trioxo-6-(propan-2-yl)-3-oxa-5,8,11-triazatridecan-13-oate 
• 452956-83-1 (2R,3R,4R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxy-2,4-dimethyloctadecanoic acid 

Relevant academic research and scientific papers

Formal total synthesis of stevastelins B and B3

The formal total synthesis of stevastelins B and B3 (2 and 4, resp.) have been accomplished employing a highly enantiomerically controlled Lewis acid catalyzed non-aldol approach to obtain the syn aldol product and temperature controlled hydroboration oxidation reaction to construct four consecutive stereogenic centers. The other key reactions include Sharpless asymmetric epoxidation, macrolactonization, and macrolactamization towards building the core skeleton 2 and 4. Copyright

Total synthesis of stevastelin B3

The total synthesis of stevastelin B3 was achieved using, as a key step, a method developed by us for the synthesis of 2-methyl-1,3-diols by Ti(III)-mediated diastereo- and regioselective opening of trisubstituted 2,3-epoxy alcohols, to carry out the ster