453-12-3

Usage

Functional groups

Ketone, Chlorine atom, Fluorine atom

Structure

Chlorine atom bonded to the first carbon, fluorine atom bonded to the third carbon, and a carbonyl group bonded to the second carbon

Applications

Organic synthesis, medicinal chemistry, building block for pharmaceuticals and other chemicals

Potential uses

Solvent, reagent in chemical reactions

Factors affecting properties and uses

Purity, concentration, and intended application

InChI:InChI=1/C3H4ClFO/c4-1-3(6)2-5/h1-2H2

Upstream product

• 186581-53-3 diazomethane 
• 359-14-8 2-chloroacetyl fluoride 
• 146580-24-7 1-chloro-3-fluoroisopropanol 
• 430-51-3 1-fluoro-2-propanone 

Downstream Products

• 766-28-9 2-chloromethyl-2-fluoromethyl-[1,3]dioxolane 
• 62522-71-8 1-Acetoxy-3-fluorpropen-2-on 
• 82754-87-8 (1-fluoroacetonyl)-triphenylphosphonium chloride 
• 1217486-96-8 N-(4-fluoromethyl-thiazol-2-yl)-acetamide 

Relevant academic research and scientific papers

Biocatalyzed synthesis of both enantiopure fluoromisonidazole antipodes

Fluoromisonidazole (FMISO or F-MISO) is a radiotracer for positron emission tomography when 18F-labeled and is administrated in its racemic form. Herein, a straightforward synthesis of both enantiopure antipodes is proposed through a one-pot two-step microwave protocol to obtain a fluorinated ketone precursor followed by bioreduction using alcohol dehydrogenases from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH).

ORGANIC COMPOUNDS

The present invention relates to a compound of formula (I) (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.