453-16-7

Basic information

• Product Name: 3-FLUORO-1,2-PROPANEDIOL
• Synonyms: 3-FLUORO-1,2-PROPANEDIOL;ALPHA-FLUOROHYDRIN;3-fluoro-2-propanediol;α-fluorohydrin;3-Fluoropropane-1,2-diol;1-Fluoro-2,3-propanediol;1,2-Propanediol,3-fluoro-
• CAS NO: 453-16-7
• Molecular Formula: C₃H₇FO₂
• Molecular Weight: 94.08
• Mol File: 453-16-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 102-103 °C13 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.1 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0197mmHg at 25°C
• Refractive Index: n20/D 1.422(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-FLUORO-1,2-PROPANEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-1,2-PROPANEDIOL(453-16-7)
• EPA Substance Registry System: 3-FLUORO-1,2-PROPANEDIOL(453-16-7)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 2810 6.1/PG 2
• WGK Germany: 3
• RTECS: TY6791500
• Hazardous Substances Data: 453-16-7(Hazardous Substances Data)

Usage

General Description

3-Fluoro-1,2-propanediol is a chemical compound with the molecular formula C3H7FO2. It is a colorless liquid with a slightly sweet odor, and it is primarily used as a solvent and intermediate in organic synthesis. 3-FLUORO-1,2-PROPANEDIOL is also used as a reagent in the production of pharmaceuticals and agricultural chemicals. Additionally, 3-fluoro-1,2-propanediol has potential applications in the manufacturing of polymers and as a building block in the synthesis of various chemical compounds. However, it is important to handle this chemical with care as it is considered to be moderately toxic and may cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C3H7FO2/c4-3(1-5)2-6/h3,5-6H,1-2H2

Upstream product

• 503-09-3 epifluorohydrine 
• 96-24-2 3-monochloro-1,2-propanediol 
• 556-52-5 oxiranyl-methanol 
• 34331-41-4 4-fluoromethyl-2,2-dimethyl-[1,3]dioxolane 

Downstream Products

• 57-03-4 lysophosphatidic acid 
• 32860-40-5 D-3-Deoxy-fluorglycerol-1-phosphat-dibenzylester 
• 142545-51-5 3-fluoro-1,2-propanediol 1-O-(4-methylbenzene)sulphonate 
• 32860-39-2 (2R)-3-fluoropropane-1,2-diol 
• 33644-25-6 (2S)-3-fluoropropane-1,2-diol 
• 53068-81-8 Hexadecanoic acid 1-fluoromethyl-2-hexadecanoyloxy-ethyl ester 
• 62522-66-1 4-Nitro-benzoic acid 3-fluoro-2-oxo-propyl ester 
• 62522-65-0 1-Benzoyloxy-3-fluorpropan-2-on 
• 62522-72-9 3-fluoro-1,2-propanediol 1-O-benzoate 
• 60007-88-7 1-fluoro-3-(triphenylmethoxy)propan-2-ol 

Relevant articles and documents

The effects of substituting groups in cyclic carbonates for stable SEI formation on graphite anode of lithium batteries

Monofluoropropylene carbonate (MFPC) and trifluoropropylene carbonate (TFPC) with a monofluoromethyl (or trifluoromethyl) replacing the methyl group in propylene carbonate (PC) as well as EC-CH2CH2Si(CH3)2OSi(CH3)3 (Si-A) and EC-CH2CH2Si(CH3)3 (Si-B) have been synthesized. The charge-discharge studies in a Li/MCMB (mesocarbon microbeads) cell using electrolyte containing these compounds show that the solid electrolyte interphase (SEI) formation capability of MFPC/DMC (dimethyl carbonate) and TFPC/DMC are about the same as ethylene carbonate (EC)/DMC, and TFPC/PC/DMC is better than that of EC/PC/DMC, while MFPC/PC/DMC is poorer than the EC/PC/DMC. The superior SEI formation capability of TFPC could be attributed to the strong electron withdrawing group of CF3, which promote the "ring-opening" reaction. In contrast, the electron donating group CH3 in the PC structure may demote the "ring opening" and cause the poor SEI formation. The results of MFPC with weaker electron withdrawing group give further support of this hypothesis. The bi-solvent electrolytes of Si-A/DMC and Si-B/DMC have comparable SEI formation capability as EC/DMC and TFPC/DMC, regardless of their bulky chains. This indicates that if proper chain structures are used, good SEI formation capability could be obtained for cyclic carbonate with bulky chains. These new solvents provide valuable information in studying the SEI formation mechanism and designing new electrolytes.

TETRABUTYLAMMONIUM DIHYDROGENTRIFLUORIDE: AN EFFICIENT CATALYST FOR REGIO AND STEREOSELECTIVE CONVERSION OF EPOXIDES TO FLUOROHYDRINS UNDER SOLID-LIQUID PHASE-TRANSFER CATALYSIS CONDITIONS.

Tetrabutylammonium dihydrogentrifluoride is an efficient and easy-to-handle hydrofluorating agent in the ring-opening reaction of oxiranes to give good or excellent yields of fluorohydrins under solid-liquid PTC conditions.