4533-96-4

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-NITROBENZENESULFONYL CHLORIDE is used as a key intermediate in the synthesis of various pharmaceuticals. It plays a crucial role in the production of sulfonamides, which are important classes of antibiotics known for their antimicrobial properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-2-NITROBENZENESULFONYL CHLORIDE is employed as a reagent for the synthesis of various agrochemicals. Its reactivity allows for the development of compounds that can be used in crop protection and pest control.
Used in Dye and Pigment Industry:
4-CHLORO-2-NITROBENZENESULFONYL CHLORIDE is used as a starting material in the manufacturing of dyes and pigments. Its unique chemical structure contributes to the development of specialty dyes and pigments with specific color properties and applications.
Used in Specialty Chemicals Production:
4-CHLORO-2-NITROBENZENESULFONYL CHLORIDE is also utilized in the production of other specialty chemicals, where its reactivity and functional groups are essential for creating unique chemical entities with specific applications in various industries.
Safety Precautions:
Due to the high reactivity and potential health hazards of 4-CHLORO-2-NITROBENZENESULFONYL CHLORIDE, it must be handled with extreme care. It should be used in a well-ventilated environment, and appropriate protective equipment, such as gloves, goggles, and respirators, should be worn to minimize exposure risks.

InChI:InChI=1/C6H3Cl2NO4S/c7-4-1-2-6(14(8,12)13)5(3-4)9(10)11/h1-3H

Upstream product

• 27165-22-6 2-nitro-4-chlorobenzenediazonium cation 
• 2050-66-0 bis(2-nitro-4-chlorophenyl)disulfide 
• 89-63-4 4-Chloro-2-nitroaniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 855294-59-6 thiobenzoic acid S-(4-chloro-2-nitro-phenyl ester) 

Downstream Products

• 13852-81-8 4-chloro-2-nitrobenzene-1-sulfonamide 
• 2719-66-6 4-chloro-2-nitro-benzenesulfinic acid 
• 1227476-15-4 Azobenzene 
• 92-87-5 p,p'-diaminobiphenyl 
• 89793-18-0 4-chloro-2-nitro-benzenesulfonic acid methylamide 
• 860558-99-2 4-chloro-2-nitro-benzenesulfonic acid-(4-amino-anilide) 
• 97426-93-2 1,4-bis-(4-chloro-2-nitro-benzenesulfonylamino)-benzene 
• 132749-54-3 N-(2-bromophenyl)-2-nitro-4-chlorobenzenesulfonamide 
• 107197-00-2 N-(4-chloro-2-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid 
• 51144-97-9 1-(4-chloro-2-nitrobenzenesulfonyl)-1H-pyrrole 
• 163460-54-6 2-ethoxycarbonyl-1-(4-chloro-2-nitrobenzenesulfonyl)-1H-pyrrole 
• 173908-13-9 1-(4-Chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 871714-01-1 4-chloro-N-(2-chloro-3-pyridyl)-2-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

A process for the preparation of substituted benzene sulfonyl chloride

The invention provides a preparation method of a pesticide intermediate, and in particular relates to a preparation method of substituted benzene sulfonyl chloride. The preparation method comprises the following steps: by taking substituted aniline as a raw material, first, carrying out diazo-reaction with sodium nitrite; then, carrying out chlorosulfonation with thionyl chloride aqueous liquor containing a catalyst to prepare substituted benzene sulfonyl chloride, wherein the yield ranges from 78% to 91%. The preparation method provided by the invention simplifies the reaction step, is safe to operate, mild in reaction conditions which are easy to control and low in equipment demand, the yield is improved, the production cost is lowered, emission of the three wastes is reduced, and the environment-friendly load is reduced, so that the preparation method is suitable for industrialized production.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

Aqueous process chemistry: The preparation of aryl sulfonyl chlorides

The use of aqueous acidic conditions for the preparation of arylsulfonyl chlorides from diazonium salts in the presence of copper salts, preferably CuCl, together with thionyl chloride as the sulfur dioxide source, has considerable advantages over recommended literature procedures, whereby reactions are carried out in acetic acid with minimisation of water content of the solvent. The method has been shown to be successful for a wide range of electron-deficient and electron-neutral aryl substrates. The sulfonyl chlorides are protected from hydrolysis by their low solubility in water, which results in their direct precipitation from the reaction mixture in good yields (>70%) and high strength (>98% w/w). The aqueous process, which is additionally safer and more robust, can be readily scaled up and has significant environmental benefits.

OXINDOLE DERIVATIVES

There is provided compounds of the formula wherein R6, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents.

Novel benzopyridothiadiazepines as potential active antitumor agents

The synthesis of novel thiadiazepine derivatives, that could be considered as constraint analogues of E-7010, are reported. These molecules were evaluated for their antiproliferative activity toward the murine L1210 leukemia cell line. Flow cytometric studies performed on L1210 cells with the most cytotoxic compounds showed an accumulation of the cells in the G2/M phases of the cell cycle with a significant percentage of tetraploid cells (8N DNA content). Submicromolar cytotoxicities were observed with compounds 2b, 4b, 4e, 4g, and 4i. Two of them, compounds 2b and 4b, were found to be potent inhibitors of tubulin polymerization with IC50 of respectively 3.8 and 2.4 μM compared to 2.4 μM for desoxypodophyllotoxin. A 4-methoxyphenylethyl substitution on the pyridinyl nitrogen of the benzopyridothiadiazepine was found to be essential for the antiproliferative activity. The in vitro activities of compounds 2b and 4b make benzopyridothiadiazepine dioxides a promising new class of tubulin binders which warrant further in vivo evaluation.