453509-72-3Relevant academic research and scientific papers
Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes
Banfi, Luca,Guanti, Giuseppe,Riva, Renata,Basso, Andrea,Calcagno, Emiliano
, p. 4067 - 4069 (2007/10/03)
Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection-transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.
Passerini multicomponent reaction of protected α-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors
Banfi, Luca,Guanti, Giuseppe,Riva, Renata
, p. 985 - 986 (2007/10/03)
Three-component Passerini condensation of N-Boc-α-aminoaldehydes with various isocyanides and carboxylic acids leads, after Boc- deprotection/transacylation, to complex peptide-like structures containing an α-hydroxy-β-aminoacid unit or, after oxidation,
