453509-74-5

Basic information

• Product Name: N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide
• Synonyms: N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide
• CAS NO: 453509-74-5
• Molecular Weight: 511.705
• Mol File: 453509-74-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide(453509-74-5)
• EPA Substance Registry System: N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide(453509-74-5)

Safety Data

• Hazardous Substances Data: 453509-74-5(Hazardous Substances Data)

Upstream product

• 701-97-3 cyclohexanepropionic acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 851029-13-5 (S)-2-(carboxy-hydroxy-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 108-91-8 cyclohexylamine 
• 453509-73-4 2-[(2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-cyclohexylcarbamoyl-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 

Relevant articles and documents

Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes

Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection-transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.