453518-19-9

Usage

Preparation

Obtained by reaction of nitric acid with 3-hydroxy-propiophenone in acetic acid at 70° (30–35%).

Upstream product

• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 455-67-4 1-(3-fluorophenyl)propan-1-one 
• 403-54-3 m-Fluorobenzonitrile 
• 458-02-6 3-fluorobenzaldehyde oxime 
• 456-48-4 3-Fluorobenzaldehyde 
• 924648-17-9 1-(5-fluoro-2-nitrophenyl)propan-1-one 
• 453518-18-8 1-(5-benzyloxy-2-nitrophenol)-2-propen-1-one 

Downstream Products

• 708254-65-3 1-[2-nitro-5-(2-piperidin-1-yl-ethoxy)-phenyl]-propan-1-one 
• 35364-15-9 2'-amino-5'-hydroxypropiophenone 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 97682-44-5 irinotecan 
• 100286-90-6 irinotecan hydrochloirde 
• 708254-67-5 1-[2-amino-5-(2-piperidin-1-yl-ethoxy)-phenyl]-propan-1-one 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF 2-AMINO-5-HYDROXY PROPIOPHENONE

The present invention relates to a process for preparation of 2-Amino-5-hydroxypropiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

Scalable synthetic route to 2-amino-5-hydroxypropiophenone: Efficient formal synthesis of irinotecan

2-Amino-5-hydroxypropiophenone, a key precursor in the total synthesis of irinotecan, has been synthesized. Regioselective nitration and a SNAr displacement are the key steps involved in this strategy, which is high yielding, is economical, and has been performed on a plant scale. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Method of Synthesizing Key Intermediates for the Production of Camptothecin Derivatives

The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES

The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents

An assessment of structure-activity relationships associated with the new benzo[5,6]pyrrolizino[1,2-b]quinoline system displaying potent in vitro cytotoxic activity against the MCF7 cell line is described.

METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS

The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.