453524-69-1

Basic information

• Product Name: tert-butyl (5S,8S)-3-(4-methoxyphenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-N-Boc-8-carboxylate
• Synonyms: tert-butyl (5S,8S)-3-(4-methoxyphenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-N-Boc-8-carboxylate
• CAS NO: 453524-69-1
• Molecular Weight: 432.517
• Mol File: 453524-69-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (5S,8S)-3-(4-methoxyphenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-N-Boc-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (5S,8S)-3-(4-methoxyphenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-N-Boc-8-carboxylate(453524-69-1)
• EPA Substance Registry System: tert-butyl (5S,8S)-3-(4-methoxyphenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-N-Boc-8-carboxylate(453524-69-1)

Safety Data

• Hazardous Substances Data: 453524-69-1(Hazardous Substances Data)

Upstream product

• 84348-38-9 (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid 
• 3717-21-3 p-methoxyl benzaldoxime 
• 163190-46-3 tert-Butyl (2S)-N-tert-butoxycarbonyl-4-methylideneprolinate 

Downstream Products

• 453524-76-0 (5S,8S)-3-(4-methoxyphenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-N-Boc-8-carboxylic acid 

Relevant articles and documents

Stereoselective synthesis of unnatural spiroisoxazolinoproline-based amino acids and derivatives

A route to spiroisoxazolinoproline-based amino acid derivatives is reported in which exomethyleneprolinate 4 (tert-butyl ester) reacts as a dipolarophile with nitrile oxides to generate spiroisoxazolinoprolinates 7/10/11 in good yields (70-75%) and with ca. 1:4 cis:trans diastereoselectivity. tert-Butyl spiroisoxazolinoprolinates were separable by column chromatography and amenable to scale-up leading to single diastereoisomers of N-Boc and N-Fmoc protected spiroisoxazolinoproline amino acids.