453560-22-0

Upstream product

• 55036-19-6 methyl [(3aS,4S,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]acetate 
• 188022-23-3 3,6-anhydro-2-deoxy-7-O-[(1,1-dimethylethyl)dimethylsilyl]-4,5-O-(1-methylethylidene)-D-allo-heptitol 
• 73556-61-3 methyl 2-(2,3-O-isopropylidene-5-O-t-butyldimethylsilyl-β-D-ribofuranosyl)acetate 

Relevant academic research and scientific papers

Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

The structure-activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1′-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study.