453560-57-1

Basic information

• Product Name: Acetamide, N-[3-bromo-5-(trifluoromethyl)phenyl]-
• CAS NO: 453560-57-1
• Molecular Formula: C9H7BrF3NO
• Molecular Weight: 282.06
• Mol File: 453560-57-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[3-bromo-5-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[3-bromo-5-(trifluoromethyl)phenyl]-(453560-57-1)
• EPA Substance Registry System: Acetamide, N-[3-bromo-5-(trifluoromethyl)phenyl]-(453560-57-1)

Safety Data

• Hazardous Substances Data: 453560-57-1(Hazardous Substances Data)

Upstream product

• 54962-75-3 [3-bromo-5-(trifluoromethyl)phenyl]amine 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 400-66-8 2-bromo-4-nitro-6-trifluoromethylaniline 
• 108761-81-5 2-bromo-4-amino-6-trifluoromethylaniline 
• 1431291-92-7 2-bromo-4-acetamido-6-trifluoromethylaniline 
• 31951-12-9 4-tert-butyl-3-nitro-phenylamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 453560-58-2 XI-N-[3-(3-piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide 
• 337535-60-1 N-[4'-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-5-(trifluoromethyl)-[1,1'-biphenyl]-3-yl]acetamide 
• 1451065-57-8 C₇H₃BrF₃O₃S^(1-)*K⁽¹⁺⁾ 
• 1451065-56-7 2-bromo-4-acetamido-6-trifluoromethybenzenesulfonic acid 
• 1431291-90-5 2-bromo-4-amino-6-trifluoromethybenzenesulfonic acid 
• 1431291-89-2 2-bromo-6-trifluoromethybenzenesulfonic acid 
• 1431291-88-1 2-bromo-6-trifluoromethybenzenesulfonyl chloride 
• 1431291-87-0 2-bromo-6-trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-yl)benzenesulfonamide 
• 219714-96-2 penoxsulam 
• 1198181-28-0 N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide 
• 1198180-44-7 ({1-[3-(methylamino)-5-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid 
• 1198181-25-7 N-[3-bromo-5-(trifluoromethyl)phenyl]-N-methylacetamide 
• 1135493-55-8 N-[3-(1-methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide 
• 1135493-45-6 N-[3-(3-morpholin-4-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide 

Relevant articles and documents

An efficient synthesis of 2-(2,2-difluoroethoxy)-6-trifluoromethyl-n-(5,8- dimethoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-yl) benzenesulfonamide: Penoxsulam

An efficient nine-step synthesis of 2-(2,2-difluoroethoxy)-6- trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c] - pyrimidine-2-yl) benzenesulfonamide has been developed. The starting material 4-nitro-2-(trifluoromethyl)aniline starting material was converted via 2-bromo-4-amino-6-trifluoromethylaniline and 2-bromo-4-acetamido-6- trifluoromethylbenzenesulfonic acid to 2-bromo-6-trilfuoromethylbenzenesulfonic acid. This was then combined with 2-amino-5,8-dimethoxy-1,2,4-triazolo[1.5-c] pyrimidine to give the target molecule. Compared with the reported method, this approach has advantages in its shorter reaction time, milder reaction conditions and easier purifiction. Moreover, the overall yield has been improved to 22.9% which is twice of that of the reported method.

HETEROCYCLIC COMPOUND

The present invention relates to a compound represented by wherein each symbol is as defined in the specification, a salt thereof and the like.

COMPOUNDS AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.