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Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-Amino-3-bromo-5-nitrobenzotrifluoride 95+% is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of new drugs and pesticides.
Used in Organic Synthesis as a Reagent:
Due to its high reactivity, 2-Amino-3-bromo-5-nitrobenzotrifluoride 95+% is employed as a reagent in organic synthesis. It can be used to form a wide range of chemical compounds, contributing to the advancement of organic chemistry.
Used in the Production of Advanced Materials and Specialty Chemicals:
2-Amino-3-bromo-5-nitrobenzotrifluoride 95+% is utilized in the manufacturing process of advanced materials and specialty chemicals. Its strong fluorinated aromatic character makes it suitable for creating high-performance materials with unique properties.
Used in Research and Industrial Applications:
The high purity level of 2-Amino-3-bromo-5-nitrobenzotrifluoride 95+% makes it suitable for use in research and industrial applications. It can be employed in various experiments and processes to achieve desired outcomes and develop innovative products.

Upstream product

• 121-01-7 4-nitro-2-trifluoromethyl-aniline 

Downstream Products

• 68105-56-6 (2-Bromo-4-nitro-6-trifluoromethyl-phenyl)-(2,4-dinitro-naphthalen-1-yl)-amine 
• 85977-20-4 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide 
• 219714-96-2 penoxsulam 
• 1431291-87-0 2-bromo-6-trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-yl)benzenesulfonamide 
• 1431291-88-1 2-bromo-6-trifluoromethybenzenesulfonyl chloride 
• 1431291-89-2 2-bromo-6-trifluoromethybenzenesulfonic acid 
• 1431291-90-5 2-bromo-4-amino-6-trifluoromethybenzenesulfonic acid 
• 1451065-56-7 2-bromo-4-acetamido-6-trifluoromethybenzenesulfonic acid 
• 1431291-92-7 2-bromo-4-acetamido-6-trifluoromethylaniline 
• 1451065-57-8 C₇H₃BrF₃O₃S^(1-)*K⁽¹⁺⁾ 
• 453560-57-1 N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide 
• 85977-21-5 2-Bromo-4-amino-6-(trifluoromethyl)acetanilide 
• 85977-22-6 N-(2-bromo-6-(trifluoromethyl)phenyl)acetamide 
• 58458-13-2 2-bromo-6-trifluoromethylphenylamine 

Relevant academic research and scientific papers

An efficient synthesis of 2-(2,2-difluoroethoxy)-6-trifluoromethyl-n-(5,8- dimethoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-yl) benzenesulfonamide: Penoxsulam

An efficient nine-step synthesis of 2-(2,2-difluoroethoxy)-6- trifluoromethyl-N-(5,8-dimethoxy-1,2,4-triazolo[1,5-c] - pyrimidine-2-yl) benzenesulfonamide has been developed. The starting material 4-nitro-2-(trifluoromethyl)aniline starting material was converted via 2-bromo-4-amino-6-trifluoromethylaniline and 2-bromo-4-acetamido-6- trifluoromethylbenzenesulfonic acid to 2-bromo-6-trilfuoromethylbenzenesulfonic acid. This was then combined with 2-amino-5,8-dimethoxy-1,2,4-triazolo[1.5-c] pyrimidine to give the target molecule. Compared with the reported method, this approach has advantages in its shorter reaction time, milder reaction conditions and easier purifiction. Moreover, the overall yield has been improved to 22.9% which is twice of that of the reported method.

SUBSTITUTED ANILINE DERIVATIVES

The present invention relates to aniline derivatives of the general formula (I) or salts thereof and their use, related to their KCNQ potassium ion channel opening activity.

SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES

The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.

Synthesis of Conformationally Defined Analogues of Norfenfluramine. A Highly Stereospecific Synthesis of Amines from Alcohols in the Benzobicycloheptene System

The synthesis of 5-, 6-, 7-, and 8-(trifluoromethyl)benzonorbornen-2-yl alcohols 6a-9a (exo) and 11a-14a (endo) and an examination of the stereospecificity of the conversion to amines via phthalimides are reported.The exo alcohols were prepared from 5-(trifluoromethyl)benzonorbornadiene (16) and 6-(trifluoromethyl)benzonorbornadiene (23) by hydroboration-oxidation.The endo alcohols were available from the corresponding exo alcohols by oxidation to the benzonorbornen-2-ones 24 (5-CF3), 25 (6-CF3), 26 (7-CF3), and 27 (8-CF3) followed by diborane reduction.While in the presence of the electron-withdrawing CF3 group the exo alcohols gave predominantly the endo amines, the endo alcohols afforded exclusively the exo amines.