453566-16-0Relevant academic research and scientific papers
NUCLIDE LABELLED H-TETRAZINES AND USE THEREOF FOR PET AND SPECT PRETARGETED IMAGING AND RADIONUCLIDE THERAPY
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Page/Page column 64-65, (2021/11/20)
The present invention relates to novel tetrazine compounds for use in pretargeted in vivo imaging and in therapy and to the precursors of the tetrazine compounds. The compounds are suitable for use in click chemistry, i.e. reactions that join a targeting
Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids
Kopp, Felix,Wunderlich, Stefan,Knochel, Paul
, p. 2075 - 2077 (2008/02/09)
The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield. The Royal Society of Chemistry.
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
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, (2008/06/13)
The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
