4543-56-0

Basic information

• Product Name: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE
• Synonyms: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE;2-hydroxy-3-methyl-8-oxa-4-azabicyclo[4.3.0]nona-1,3,5-trien-7-one;5-Pyridoxolactone;5-pyridoxic acid lactone;7-Hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one;Pyracin-5;Pyridoxic acid γ-lactone;3-Carboxy-4-(hydroxymethyl)-5-hydroxy-6-methylpyridine lactone
• CAS NO: 4543-56-0
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 4543-56-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 511.2°Cat760mmHg
• Flash Point: 263°C
• Appearance: /
• Density: 1.448g/cm³
• Vapor Pressure: 4.52E-11mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: ?20°C
• Solubility: Methanol
• CAS DataBase Reference: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE(4543-56-0)
• EPA Substance Registry System: 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE(4543-56-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 4543-56-0(Hazardous Substances Data)

Usage

Uses

5-Pyridoxolactone is an intermediate in the synthesis of analogues of Pyridoxine (P991735), one of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). Pyridoxine has a role in transporting protein Bsu1, Pyridoxine contributes to thiamine uptake; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.

Definition

ChEBI: A furopyridine that is furo[3,4-c]pyridin-3(1H)-one substituted by a hydroxy group at position 7 and a methoxy group at position 6. It is a metabolite of vitamin B6.

General Description

5-pyridoxolactone is a metabolite of vitamin B6.

Biochem/physiol Actions

5-Pyridoxolactone is a normal human metabolite of vitamin B6 metabolism.

InChI:InChI=1/C8H7NO3/c1-4-7(10)6-3-12-8(11)5(6)2-9-4/h2,10H,3H2,1H3

Upstream product

• 105106-29-4 5-acetoxy-4-acetoxymethyl-6-methyl-nicotinic acid 
• 62489-21-8 9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester 
• 1198621-03-2 N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide 
• 1198621-04-3 N,3-bis(benzyloxy)-4,5-bis(hydroxymethyl)picolinamide 
• 1198621-05-4 N,7-bis(benzyloxy)-3-oxo-1,3-dihydrofuro[3,4-c]pyridine-6-carboxamide 
• 1198620-33-5 N,3-bis(benzyloxy)-4-(hydroxymethyl)-N-(4-methoxybenzyl)pyridine-2,5-dicarboxamide 
• 6560-65-2 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxaldehyde 
• 6932-32-7 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxylic acid methyl ester 
• 1626-11-5 5-Carbamoyl-2,2,8-trimethyl-4H-m-dioxino<4,5-c>pyridin 
• 1626-12-6 5-Amino-2,2,8-trimethyl-4H-m-dioxino<4,5-c>pyridin 
• 1136-52-3 (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 
• 17718-67-1 4-(ethoxymethyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 99768-47-5 (3-amino-5-aminomethyl-2-methyl-[4]pyridyl)-methanol; dihydrochloride 
• 60690-80-4 4-(acetoxymethyl)-5-(hydroxymethyl)-2-methylpyridin-3-yl acetate 

Downstream Products

• 1198621-48-5 C₃₂H₃₅FN₂O₃Si 
• 1198621-47-4 C₁₆H₁₇FN₂O₃ 

Relevant articles and documents

HIV INTEGRASE INHIBITORS FROM PYRIDOXINE

The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HΙV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.

Chemistry of salicylic acid and anthranilic acid. I. Reduction of methyl salicylate, methyl anthranilate and their derivatives with sodium borohydride

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