4543-56-0

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE is used as an intermediate in the synthesis of Pyridoxine analogues for the development of pharmaceutical products targeting various health conditions. Its role in the transport of protein Bsu1 and thiamine uptake makes it a valuable component in the formulation of vitamin supplements and therapeutic agents.
Used in Nutritional Supplements:
In the nutritional supplement industry, 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE is used as a precursor for the production of Pyridoxine, which is an essential component of B6 complex vitamins. These supplements help maintain optimal health and support various bodily functions, including the proper functioning of the nervous system and the synthesis of amino acids.
Used in Food Fortification:
2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE is used as a fortifying agent in the food industry to enhance the nutritional value of food products. By incorporating 2-METHYL-3-HYDROXY-4-HYDROXYMETHYL-5-CARBOXYPYRIDINE LACTONE into food items, manufacturers can ensure that consumers receive an adequate amount of Pyridoxine and other essential nutrients, contributing to overall health and well-being.

Biochem/physiol Actions

5-Pyridoxolactone is a normal human metabolite of vitamin B6 metabolism.

InChI:InChI=1/C8H7NO3/c1-4-7(10)6-3-12-8(11)5(6)2-9-4/h2,10H,3H2,1H3

Upstream product

• 18872-74-7 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 94934-46-0 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carbonitrile 
• 7472-18-6 6-Methyl-1H-furano<3,4-c>pyridine-3,4(5H)-dione 
• 6560-65-2 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxaldehyde 
• 62489-21-8 9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester 
• 1198621-03-2 N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide 
• 1198621-04-3 N,3-bis(benzyloxy)-4,5-bis(hydroxymethyl)picolinamide 
• 1198621-05-4 N,7-bis(benzyloxy)-3-oxo-1,3-dihydrofuro[3,4-c]pyridine-6-carboxamide 
• 1198620-33-5 N,3-bis(benzyloxy)-4-(hydroxymethyl)-N-(4-methoxybenzyl)pyridine-2,5-dicarboxamide 
• 6932-32-7 2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxylic acid methyl ester 
• 1626-11-5 5-Carbamoyl-2,2,8-trimethyl-4H-m-dioxino<4,5-c>pyridin 
• 1626-12-6 5-Amino-2,2,8-trimethyl-4H-m-dioxino<4,5-c>pyridin 
• 1136-52-3 (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 
• 17718-67-1 4-(ethoxymethyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 1198621-47-4 C₁₆H₁₇FN₂O₃ 
• 1198621-48-5 C₃₂H₃₅FN₂O₃Si 

Relevant academic research and scientific papers

HIV INTEGRASE INHIBITORS FROM PYRIDOXINE

The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HΙV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.

Silane reduction of 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester: Synthesis of vitamin B6

Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)2) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine. An isolation technique utilizing a commercially available resin was devised, affording the desired product, vitamin B6, in an overall yield of 38-54% and a purity of 76%.