454439-45-3Relevant academic research and scientific papers
Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii
Graffner-Nordberg, Malin,Kolmodin, Karin,Aqvist, Johan,Queener, Sherry F.,Hallberg, Anders
, p. 43 - 53 (2004)
A series of dihydrofolate reductase (DHFR) inhibitors, where the methylenamino-bridge of non-classical inhibitors was replaced with an ester function, have been prepared as potential soft drugs intended for inhalation against Pneumocystis carinii pneumoni
