454715-80-1

Upstream product

• 212970-72-4 {3-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-(1S,3R,4S,5R)-7,7-dimethyl-2,6,8-trioxa-4-(phenylmethoxy)bicyclo[3.3.0]oct-3-yl}methan-1-ol 

Downstream Products

• 454715-81-2 5-O-[(1,1-dimethylethyl)diphenylsilyl]-4-C-vinyl-3-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 1421238-34-7 3-O-benzyl-5-(O-tert-butyldiphenylsilyl)-4-C-(Z)-prop-1-enyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 1421238-37-0 3′-O-benzyl-5′-(O-tert-butyldiphenylsilyl)-2′-deoxy-4′-C-(Z)-prop-1-enyluridine 
• 1421238-36-9 2′-O-acetyl-3′-O-benzyl-5′-(O-tert-butyldiphenylsilyl)-4′-C-(Z)-prop-1-enyluridine 
• 1421238-35-8 1,2-di-O-acetyl-3-O-benzyl-5-(O-tert-butyldiphenylsilyl)-4-C-(Z)-prop-1-enyl-α,β-D-ribofuranose 
• 860651-69-0 2'-O-acetyl-3'-O-benzyl-5'-O-tert-butyldiphenylsilyl-4'-C-vinyluridine 
• 860651-71-4 3'-O-benzyl-5'-O-tert-butyldiphenylsilyl-2'-deoxy-4'-C-vinyluridine 
• 860651-74-7 2'-deoxy-5'-O-dimethoxytrityl-4'-C-ethyluridine 
• 860651-66-7 1,2-di-O-acetyl-3-O-benzyl-5-O-tert-butyldiphenylsilyl-4-C-vinyl-α,β-D-ribofuranose 
• 634153-95-0 5'-O-(tert-butyldiphenylsilyl)-4'-C-(p-toluenesulfonyloxypropyl)-3'-O-benzyl-2'-O-acetyl-5-methyluridine 
• 634153-93-8 5-O-[(1,1-dimethylethyl)diphenylsilyl]-4-C-{[(4-methylphenyl)sulfonyl]oxy}propyl-3-O-benzyl-1,2-O-(1-methylethylidene)-α-D-ribofuranose 
• 634153-98-3 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-propylene-5-methyluridine 
• 634153-91-6 5-O-(tert-butyldiphenylsilyl)-4-C-(2-ethoxycarbonylethyl)-3-O-benzyl-1,2-O-isopropylidene-α-D-erythropentofuranose 
• 634153-92-7 5-O-(tert-butyldiphenylsilyl)-4-C-hydroxypropyl-3-O-benzyl-1,2-O-isopropylidene-α-D-erythropentofuranose 

Relevant academic research and scientific papers

Synthesis of 4'-C-alkylated-5-iodo-2'-deoxypyrimidine nucleosides

Starting from available ribose-building blocks, the 4'-C-methyl-, 4'-C-ethyl- and the new 4'-Cpropyl- substituted deoxyuridines were synthesized. Afterwards we converted 4'-C-alkylated-2'- deoxyuridines into the corresponding 4'-C-alkylated-5-iodo-2'-deox

Synthesis and application of 4′-C-alkylated uridines as probes for uracil-DNA glycosylase

The development of new synthetic probes to study the mechanism of Uracil-DNA glycosylase is described. 4′-C-Alkylated 2′-deoxyuridines were synthesized and incorporated site-specifically into oligonucleotides. These compounds were subsequently employed in

Synthesis and properties of 2′-O,4′-C-ethylene-bridged nucleic acids (ENA) as effective antisense oligonucleotides

Novel bicyclo nucleosides, 2′-O,4′-C-ethylene nucleosides and 2′-O,4′-C-propylene nucleosides, were synthesized as building blocks for antisense oligonucleotides to further optimize the 2′-O,4′-C-methylene-linkage of bridged nucleic acids (2′,4′-BNA) or l