454715-81-2Relevant articles and documents
Synthesis of 4′-C-aminoalkyl-2′-O-methyl modified RNA and their biological properties
Koizumi, Kana,Maeda, Yusuke,Kano, Toshifumi,Yoshida, Hisae,Sakamoto, Taiichi,Yamagishi, Kenji,Ueno, Yoshihito
, p. 3521 - 3534 (2018)
In this paper, we describe the synthesis of 4′-C-aminoalkyl-2′-O-methylnucleosides and the properties of RNAs containing these analogs. Phosphoramidites of 4′-C-aminoethyl and 4′-C-aminopropyl-2′-O-methyluridines were prepared using glucose as starting ma
Synthesis and application of 4′-C-alkylated uridines as probes for uracil-DNA glycosylase
Rangam, Gopinath,Rudinger, Nicolas Z.,Mueller, H. Martin,Marx, Andreas
, p. 1467 - 1472 (2007/10/03)
The development of new synthetic probes to study the mechanism of Uracil-DNA glycosylase is described. 4′-C-Alkylated 2′-deoxyuridines were synthesized and incorporated site-specifically into oligonucleotides. These compounds were subsequently employed in