4551-61-5

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 98-86-2 acetophenone 
• 535-80-8 3-chlorobenzoate 
• 25487-66-5 3-Carboxyphenylboronic acid 
• 107-13-1 acrylonitrile 
• 618-51-9 3-Iodobenzoic acid 

Downstream Products

• 43019-97-2 3-deuterio-benzoyl chloride 

Relevant academic research and scientific papers

Method for synthesizing deuterated compound in aqueous phase solvent

The invention belongs to the technical field of isotope labeling chemical synthesis, and discloses a method for synthesizing a deuterated compound in an aqueous phase solvent. The method is based on the following chemical reaction equation: a halide, diaz

Water Compatible Hypophosphites- d2 Reagents: Deuteration Reaction via Deutero-deiodination in Aqueous Solution

Contrary to conventional deuteration approaches which typically entail deuterated solvents and/or moisture exclusion, an unprecedented deutero-deiodination reaction attainable in aqueous (H2O) solution is presented herein. By utilizing the stability of inorganic deuterated calcium/sodium hypophosphites against wayward H/D isotopic exchange within pH 2.5-11.7, these shelf-stable, nontoxic, cost-effective, and environmentally benign deuteration reagents mediate deuteration of a broad range alkyl and aryl iodides with ample isotopic incorporation in aqueous (H2O) solution.

Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate

A selective continuous-flow (CF) deuterodehalogenation approach is described performed in propylene carbonate, which is considered as one of the greenest solvents. Various CF technologies are known for hydrodehalogenation reactions; however, they are not

A strategy for generating aryl radicals from arylborates through organic photoredox catalysis: Photo-Meerwein type arylation of electron-deficient alkenes

Photoinduced reactions of arylboronic acids with electron deficient alkenes under mild organic photoredox catalysis conditions lead to the formation of Meerwein arylation type adducts via the generation of aryl radicals.

Deuterodechlorination of Aryl/Heteroaryl Chlorides Catalyzed by a Palladium/Unsymmetrical NHC System

The catalytic deuterodechlorination of aryl/heteroaryl chlorides was developed with a palladium/unsymmetrical NHC system, and the precisely controlled introduction of deuterium into a variety of aryl/heteroaryl compounds was achieved with a high level of efficiency, selectivity, and deuteration degree. This method was also successfully applied to the transformation of bioactive agents even in a gram-scale synthesis. The crystal structure analysis of Pd-NHC complexes led to the observation of Pd-arene interaction.

PREPARATION OF DEUTERIATED 1-PHENYLETHANOLS BY REDUCTIVE DEHALOGENATION OF THE CORRESPONDING HALOGENOACETOPHENONES WITH RANEY ALLOYS IN AN ALKALINE DEUTERIUM OXIDE SOLUTION

Deuteriated 1-phenylethanols were prepared by reductive dehalogenation of the corresponding halogenoacetophenones with Raney Ni-Al and Cu-Al alloys in 5percent NaOD-D2O solution.It was found that the Ni-Al alloy introduced greater than expected numbers of deuterium atoms in the phenyl ring, but the expected deuteriated 1-phenylethanols were obtained in high yield and in high isotopic purity when Raney Cu-Al alloy was used.

Preparation of All the Possible Ring-deuteriated Benzoic Acids by Reductive Dehalogenation of the Corresponding Halogenobenzoic Acids with Raney Alloys in an Alkaline Deuterium Oxide Solution

All the possible undeuteriated benzoic acids were prepared mainly by treatment of the corresponding bromobenzoic acid with Raney Cu-Al alloy in 10percent NaOD-D2O solution. 5>Benzoic acid was obtained from pentafluorobenzoic acid by a similar reaction.However, only 4>benzoic acid was prepared by decarboxylation of 4>phthalic acid.

REDUCTION OF HALOBENZOIC ACIDS TO DEUTERATED BENZOIC ACIDS WITH RANEY ALLOYS IN NaOD-D2O SOLUTION

Reduction of bromobenzoic acids with Raney Cu-Al alloy in 10percent NaOD-D2O solution afforded the corresponding deuterated benzoic acids in high yields and in high isotopic purities.However, use of Raney Ni-Al alloy instead of Cu-Al alloy leads to the in