455330-53-7

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 455330-43-5 (3S,4S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-cyclohexanone 
• 96894-00-7 (1S,2S)-4,4-ethylenedioxy-2-hydroxymethylcyclohexanol 
• 96893-99-1 (1R,2S)-5,5-(Ethylendioxy)-2-hydroxycyclohexancarbonsaeure-ethylester 
• 96817-54-8 ethyl (1R,2S)-2-acetoxy-5,5-ethylenedioxycyclohexanecarboxylate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 455330-52-6 (7S,8S)-7-(tert-Butyl-diphenyl-silanyloxymethyl)-1,4-dioxa-spiro[4.5]decan-8-ol 

Downstream Products

• 163513-98-2 (-)-(1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate 
• 455330-54-8 (1R,3R,4R)-4-Azido-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohexanol 
• 455330-46-8 2-(tert-butyl-diphenyl-silanyloxymethyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester 
• 455330-45-7 Methanesulfonic acid (1R,3R,4R)-4-azido-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohexyl ester 
• 455330-55-9 methanesulfonic acid 4-tert-butoxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxymethyl)-cyclohexyl ester 
• 455330-44-6 Methanesulfonic acid (1S,2S,4R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-cyclohexyl ester 

Relevant academic research and scientific papers

Enantioselective synthesis of (-)-N-Boc-7-azabicyclo-[2.2.1]heptan-2-one and (+)-N-Boc-4-amino-2-cyclohexen-1-one: Formal total synthesis of both enantiomers of epibatidine

We succeeded in the stereoselective synthesis of (-)-N-Boc-7-azabicyclo[2.2.1]heptan-2-one ((-)-2) and (+)-N-Boc-4-amino-2-cyclohexen-1-one ((+)-3), key intermediates to (-) and (+)-epibatidine from a common chiral building block ethyl (1R,2S)-5,5-ethylen