4558-87-6

Basic information

• Product Name: 2,5-dimethylpiperidin-4-one
• Synonyms: 4-piperidinone, 2,5-dimethyl-
• CAS NO: 4558-87-6
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.1842
• Mol File: 4558-87-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 192.8°C at 760 mmHg
• Flash Point: 80.5°C
• Density: 0.915g/cm³
• Vapor Pressure: 0.48mmHg at 25°C
• Refractive Index: 1.43
• CAS DataBase Reference: 2,5-dimethylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethylpiperidin-4-one(4558-87-6)
• EPA Substance Registry System: 2,5-dimethylpiperidin-4-one(4558-87-6)

Safety Data

• Hazardous Substances Data: 4558-87-6(Hazardous Substances Data)

Usage

General Description

2,5-dimethylpiperidin-4-one is a chemical compound with the molecular formula C7H13NO. It belongs to the piperidine class of organic compounds and is used in the synthesis of pharmaceuticals and agrochemicals. This chemical is a colorless liquid with a characteristic amine-like odor. It is primarily used as a building block in the manufacture of various drugs and agricultural chemicals. 2,5-dimethylpiperidin-4-one has a variety of industrial applications and is an important intermediate in the production of many different types of compounds.

Upstream product

• 93583-33-6 trans-1-α-Phenylethyl-2R,5S-dimethyl-4-piperidone 
• 93583-33-6 1-α-Phenylethyl-2S,5ξ-dimethyl-4-piperidone 
• 1252678-28-6 ethyl 3-{[3-ethoxy-2-methyl-3-oxopropyl]amino}butanoate 
• 220094-93-9 (1-methyl-2-ethoxycarbonylethyl)-(2-methyl-2-methoxycarbonylethyl)amine 
• 13058-39-4 (E)-2-methylhexa-1,4-dien-3-one 
• 41854-15-3 1,5-dimethoxy-2-methyl-hexan-3-one 

Downstream Products

• 39167-89-0 4-(3-buten-1-ynyl)-2,5-dimethylpiperidin-1-ol 
• 101496-66-6 2,5-dimethyl-1-(4-nitro-phenethyl)-piperidin-4-one 
• 109938-17-2 (2,5-dimethyl-4-oxo-piperidino)-phenyl-acetic acid methyl ester 
• 58476-13-4 2,5-dimethyl-4-oxo-piperidine-1-carboxylic acid ethyl ester 
• 101599-55-7 2,5-dimethyl-1-(3,4,5-trimethoxy-benzoyl)-piperidin-4-one 
• 63791-75-3 1-benzyl-2,5-dimethyl-piperidin-4-one 
• 107521-94-8 1-benzoyl-2,5-dimethyl-piperidin-4-one 
• 101939-13-3 2,5-dimethyl-1-(4-nitro-benzoyl)-piperidin-4-one 
• 102005-13-0 (+/-)-1-acetyl-2c,5c-dimethyl-4-phenyl-piperidin-4r-ol 
• 29280-78-2 1-(2-phenylethyl)-2,5-dimethyl-4-piperidone 
• 101105-60-6 2,5-dimethyl-4-oxo-piperidine-1-carboxylic acid benzyl ester 
• 102075-52-5 1-cinnamyl-2,5-dimethyl-piperidin-4-one 
• 100610-12-6 1-benzenesulfonyl-2,5-dimethyl-piperidin-4-one 
• 101738-79-8 2,5-dimethyl-1-(3-methyl-but-2-enyl)-piperidin-4-one 

Relevant articles and documents

Commercial synthesis of 2,5-dimethylpiperid-4-one

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ASYMMETRIC SYNTHESIS AND ABSOLUTE CONFIGURATION OF 1-α-PHENYLETHYL-2,5-DIMETHYL-4-PIPERIDONE ISOMERS

Reaction of the methyl iodide of trans-1,2-5-trimethyl-4-piperidone with S-α-phenylethylamine proceeds asymmetrically and leads in 66percent optical yield to the formation of the cis- and trans-diastereomeric pair of 1-(α-phenylethyl)-2,5-dimethyl-4-piperidone, in which the new asymmetric centers possess the 2S,5S- and 2S,5R-configurations, respectively.According to x-ray structural analysis, the minor trans-1-(α-phenylethyl)-2,5-dimethyl-4-piperidone component possesses the 2R,5S-configuration.The occurrence of asymmetric synthesis accompanying transamination was confirmed via the preparation of enantiomers of trans-2,5- and trans-1,2,5-trimethyl-4-piperidones.