93583-33-6

Basic information

• Product Name: trans-1-α-Phenylethyl-2R,5S-dimethyl-4-piperidone
• CAS NO: 93583-33-6
• Molecular Weight: 231.338
• Mol File: 93583-33-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: trans-1-α-Phenylethyl-2R,5S-dimethyl-4-piperidone(CAS DataBase Reference)
• NIST Chemistry Reference: trans-1-α-Phenylethyl-2R,5S-dimethyl-4-piperidone(93583-33-6)
• EPA Substance Registry System: trans-1-α-Phenylethyl-2R,5S-dimethyl-4-piperidone(93583-33-6)

Safety Data

• Hazardous Substances Data: 93583-33-6(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 29280-77-1 1,2,5-trimethylpiperidin-4-one iodomethylate 

Downstream Products

• 7516-33-8 trans-1,2R,5S-Trimethyl-4-piperidone 
• 7516-33-8 trans-1,2S,5R-Trimethyl-4-piperidone 
• 4558-87-6 trans-2R,5S-Dimethyl-4-piperidone 
• 4558-87-6 trans-2S,5R-Dimethyl-4-piperidone 

Relevant articles and documents

ASYMMETRIC SYNTHESIS AND ABSOLUTE CONFIGURATION OF 1-α-PHENYLETHYL-2,5-DIMETHYL-4-PIPERIDONE ISOMERS

Reaction of the methyl iodide of trans-1,2-5-trimethyl-4-piperidone with S-α-phenylethylamine proceeds asymmetrically and leads in 66percent optical yield to the formation of the cis- and trans-diastereomeric pair of 1-(α-phenylethyl)-2,5-dimethyl-4-piperidone, in which the new asymmetric centers possess the 2S,5S- and 2S,5R-configurations, respectively.According to x-ray structural analysis, the minor trans-1-(α-phenylethyl)-2,5-dimethyl-4-piperidone component possesses the 2R,5S-configuration.The occurrence of asymmetric synthesis accompanying transamination was confirmed via the preparation of enantiomers of trans-2,5- and trans-1,2,5-trimethyl-4-piperidones.