455901-16-3Relevant academic research and scientific papers
Compounds for the treatment of protozoal diseases
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, (2008/06/13)
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C=O, C=S, C=NH, (C=O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.
Sulfonyl-phenyl-ureido benzamidines: A novel structural class of potent antimalarial agents
Leban, Johann,Pegoraro, Stefano,Dormeyer, Matthias,Lanzer, Michael,Aschenbrenner, Andrea,Kramer, Bernd
, p. 1979 - 1982 (2007/10/03)
The high throughput in silico screening of a virtual library into the structure of the P. falciparum lactate dehydrogenase (LDH) with the 4SCan technology yielded a series of biphenyl urea compounds. These were chemically optimized to a new structural class of potent antimalarial agents. The compounds did not inhibit plasmodium LDH enough to fully explain their potency. Therefore we conclude that an unknown mode of action may be the cause of the antimalarial activity.
Compounds for the treatment of protozoal diseases
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, (2008/06/13)
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.
Compounds for the treatment of protozoal diseases
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, (2008/06/13)
Treatment of Protozoan Infections with new diphenylurea derivatives.
